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Challenging the model for induction of metallothionein gene expression

dc.rights.licenseopenen_US
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBOURDINEAUD, Jean-Paul
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBAUDRIMONT, Magalie
IDREF: 105696722
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorGONZALEZ, Patrice
ORCID: 0000-0003-2628-2993
IDREF: 14341917X
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorMOREAU, J.-L.
dc.date.accessioned2024-04-15T16:35:52Z
dc.date.available2024-04-15T16:35:52Z
dc.date.issued2006-11-01
dc.identifier.issn0300-9084en_US
dc.identifier.urihttps://www.researchgate.net/publication/6853881_Challenging_the_model_for_induction_of_metallothionein_gene_expression
dc.identifier.urioai:crossref.org:10.1016/j.biochi.2006.07.021
dc.identifier.urioai:researchgate.net:6853881
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199021
dc.description.abstractEnMetallothioneins (MTs) are low-molecular-weight, cysteine-rich metal-binding proteins found in a wide variety of organisms including bacteria, fungi and all eukaryotic plant and animal species. MTs bind essential and non-essential heavy metals. In mammalian cells MT genes are highly inducible by many heavy metals including Zn, Cd, Hg, and Cu. Aquatic systems are contaminated by different pollutants, including metals, as a result of man's activities. Bivalve molluscs are known to accumulate high concentrations of heavy metals in their tissue and are widely used as bioindicators for pollution in marine and freshwater environments, with MTs frequently used as a valuable marker of metal contamination. We here describe the MT isoform gene expression patterns of marine and freshwater molluscs and fish species after Cd or Zn contamination. Contamination was carried out at a river site polluted by a zinc ore extraction plant or in the laboratory at low, environmentally relevant metal concentrations. A comparison for each species based on the accumulated MT protein levels often shows discrepancies between gene expression and protein level. In addition, several differences observed in the pattern of MT gene expression between mollusc and mammalian species enable us to discuss and challenge a model for the induction of MT gene expression.
dc.language.isoENen_US
dc.sourcecrossref
dc.sourceresearchgate
dc.title.enChallenging the model for induction of metallothionein gene expression
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.biochi.2006.07.021en_US
dc.subject.halSciences de l'environnementen_US
bordeaux.journalBiochimieen_US
bordeaux.page1787-1792en_US
bordeaux.volume88en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamEAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.identifierhal-04547514
hal.version1
hal.date.transferred2024-04-15T16:35:54Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
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