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Colloidal Stability of Aqueous Suspensions of Polymer-Coated Iron Oxide Nanorods: Implications for Biomedical Applications

dc.rights.licenseopen
hal.structure.identifierInstitut de Physique de Nice [INPHYNI]
dc.contributor.authorMARINS, Jéssica Alves
hal.structure.identifierInstitut de Physique de Nice [INPHYNI]
dc.contributor.authorMONTAGNON, Tom
hal.structure.identifierInstitut de Physique de Nice [INPHYNI]
dc.contributor.authorEZZAIER, Hinda
hal.structure.identifierInstitut de Physique de Nice [INPHYNI]
dc.contributor.authorHUREL, Charlotte
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSANDRE, Olivier
dc.contributor.authorBALTRŪNAS, Dalis
dc.contributor.authorMAŽEIKA, Kestutis
hal.structure.identifierScientific-Practical Materials Research Centre
dc.contributor.authorPETROV, Alexander
hal.structure.identifierInstitut de Physique de Nice [INPHYNI]
dc.contributor.authorKUZHIR, Pavel
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2018
dc.identifier.issn2574-0970
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19848
dc.description.abstractEnIron oxide nanorods are considered to be very promising platforms for biomedical applications, such as magnetic hyperthermia, magnetic resonance imaging or immunoassays based on magneto-optical effects. However, their efficient colloidal stabilization is challenging , and colloidal aggregation could lead to the total loss of their performance. This work is focused on synthesis and colloidal stabilization of iron oxide nanorods of an average length and diameter L×d=31×6 nm, synthetized by hydrolysis of iron (III) salt followed by reduction of the obtained akaganeite to iron oxide in a microwave reactor. Synthesized nanorods exhibited a weak ferrimagnetic behavior with remnant magnetization Mr ∼3 emu/g and saturation magnetization Ms ∼13 emu/g. The nanorods were dispersed in water after adsorption on their surface of three different polymers-linear bisphosphonate-polyethylene glycol (PEG) molecules (denoted OPT), polymethacrylate backbone / PEG side chains comb polymer (denoted PCP) (both with PEG brushes extended towards the solvent and having molecular weight Mw ∼3000 g/mol) and polyacrylic sodium salt (PAA, M w ∼15000 g/mol). Experiments and theoretical evaluation of the interaction potential shows that increasing polymer grafting density on the nanorod surface as well as decreasing concentration of non-adsorbed polymer improve the nanorod colloidal stability. The best stability is obtained on an optimal range of weight ratio of the added polymer to the nanorods between 0.5 and 1.6 mg/mg. Higher grafting density reached with OPT polymer with a bisphosphonate terminal group (2-4 nm-2) allows much better stability than using multiple adsorption with PCP (0.2-0.4 nm-2) or PAA. Even though the nanorods are still subject to some aggregation (effective hydrodynamic diameter ∼60 nm, as compared to their TEM size L×d=31×6 nm), significant progress towards understanding their colloidal stability was achieved.
dc.description.sponsorshipIdex UCA JEDI
dc.description.sponsorshipMagnéto-Chimiothérapie : Modélisation de la Délivrance Induite par Champ Magnétique Radiofréquence d'Anticancéreux par des Nano-Vésicules Polymères et Suivi par IRM d'un Modèle de Glioblastome - ANR-13-BS08-0017
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subject.enmagnetic nanoparticles
dc.subject.enrod-lile nanoparticles
dc.subject.encolloidal stability
dc.subject.enpolymer coating
dc.title.enColloidal Stability of Aqueous Suspensions of Polymer-Coated Iron Oxide Nanorods: Implications for Biomedical Applications
dc.typeArticle de revue
dc.identifier.doi10.1021/acsanm.8b01558
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
dc.subject.halChimie/Polymères
dc.subject.halChimie/Matériaux
bordeaux.journalACS Applied Nano Materials
bordeaux.page6760-6772
bordeaux.volume1
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue12
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01924377
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01924377v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=ACS%20Applied%20Nano%20Materials&rft.date=2018&rft.volume=1&rft.issue=12&rft.spage=6760-6772&rft.epage=6760-6772&rft.eissn=2574-0970&rft.issn=2574-0970&rft.au=MARINS,%20J%C3%A9ssica%20Alves&MONTAGNON,%20Tom&EZZAIER,%20Hinda&HUREL,%20Charlotte&SANDRE,%20Olivier&rft.genre=article


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