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Comparative Evaluation of the Toxicity and Genotoxicity of Cadmium in amphibian larvae (Xenopus laevis and Pleurodeles waltl) Using the Comet Assay and tghe Micronucleus Test

dc.rights.licenseopenen_US
dc.contributor.authorMOUCHET, Florence
dc.contributor.authorGAUTHIER, Laury
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBAUDRIMONT, Magalie
IDREF: 105696722
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorGONZALEZ, Patrice
ORCID: 0000-0003-2628-2993
IDREF: 14341917X
dc.contributor.authorMAILHES, C.
dc.contributor.authorFERRIER, V.
dc.contributor.authorDEVAUX, A.
dc.date.accessioned2024-04-15T09:46:12Z
dc.date.available2024-04-15T09:46:12Z
dc.date.issued2007-08-01
dc.identifier.issn1520-4081en_US
dc.identifier.urihttps://hal.archives-ouvertes.fr/hal-00167212
dc.identifier.urioai:crossref.org:10.1002/tox.20267
dc.identifier.urioai:researchgate.net:6229467
dc.identifier.uriftartxiker:oai:HAL:hal-00167212v1
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/197989
dc.description.abstractEnThe toxic and genotoxic potential of Cadmium (CdCl(2)) were evaluated by the micronucleus test (MNT) and comet assay (CA) using amphibian larvae (Xenopus laevis and Pleurodeles waltl). Acute toxicity results showed that Cd is toxic to Xenopus larvae exposed from 2 to 50 mg/L and to Pleurodeles from 5 to 50 mg/L, depending on the nature of the water (reconstituted water containing mineral salts or mineral water MW (Volvic)). The MNT results obtained in MW showed that Cd (2 mg/L) is genotoxic to Xenopus, whereas it was not genotoxic to Pleurodeles at all concentrations tested. The CA established that the genotoxicity of Cd to Xenopus and Pleurodeles larvae depends on the concentration, the exposure times, and the comet parameters (Tail DNA, ETM, OTM, and TL). The CA and MNT results were compared for their ability to detect genotoxic effects, considering the concentrations of Cd applied and the exposure time. The CA showed Cd to be genotoxic from the first day of exposure. In amphibians, the CA appears to be a sensitive and suitable method for detecting genotoxicity such as that caused by Cd.
dc.language.isoENen_US
dc.sourcecrossref
dc.sourceresearchgate
dc.sourcebase
dc.title.enComparative Evaluation of the Toxicity and Genotoxicity of Cadmium in amphibian larvae (Xenopus laevis and Pleurodeles waltl) Using the Comet Assay and tghe Micronucleus Test
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/tox.20267en_US
dc.subject.halSciences de l'environnementen_US
bordeaux.journalEnvironmental Toxicologyen_US
bordeaux.page422-435en_US
bordeaux.volume22en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamEAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Toxicology&rft.date=2007-08-01&rft.volume=22&rft.issue=4&rft.spage=422-435&rft.epage=422-435&rft.eissn=1520-4081&rft.issn=1520-4081&rft.au=MOUCHET,%20Florence&GAUTHIER,%20Laury&BAUDRIMONT,%20Magalie&GONZALEZ,%20Patrice&MAILHES,%20C.&rft.genre=article


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