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dc.rights.licenseopenen_US
dc.contributor.authorRAHERISON-SEMJEN, Chantal
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorGONZALEZ, Patrice
ORCID: 0000-0003-2628-2993
IDREF: 14341917X
dc.contributor.authorRENAUDIN, H.
dc.contributor.authorCHARRON, A.
dc.contributor.authorBEBEAR, Cecile
dc.date.accessioned2024-04-15T09:07:20Z
dc.date.available2024-04-15T09:07:20Z
dc.date.issued2002-03-01
dc.identifier.issn0066-4804en_US
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/11850247
dc.identifier.urioai:crossref.org:10.1128/aac.46.3.672-679.2002
dc.identifier.urioadoi:http://europepmc.org/articles/pmc127495?pdf=render
dc.identifier.uriftpubmed:oai:pubmedcentral.nih.gov:127495
dc.identifier.urioai:researchgate.net:11511634
dc.identifier.urioadoi:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127495
dc.identifier.urioadoi:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC127495/pdf
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/197586
dc.description.abstractEnABSTRACT The uptake of fluoroquinolones was characterized for the fluoroquinolone-susceptible strain PG21 of Mycoplasma hominis . Accumulation of fluoroquinolones appeared to occur by passive diffusion. Addition of arginine as the energizer significantly reduced the uptake of fluoroquinolones, suggesting the presence of an energy-dependent efflux process. Reserpine and orthovanadate, two multidrug pump inhibitors, increased significantly the ciprofloxacin (CIP) uptake. In contrast, such a strong effect was not observed for moxifloxacin and pefloxacin uptakes. Two ethidium bromide (EtBr)-resistant strains, selected in vitro, showed a resistance profile compatible with a multidrug-resistant phenotype, with increased MICs for the hydrophilic fluoroquinolones, CIP and norfloxacin, EtBr, and acriflavine. Taking the EtBr-resistant strain RB1La as a model, a significant decrease of the CIP and EtBr uptakes was observed compared to the reference strain PG21. In the presence of reserpine and orthovanadate, both inhibitors of ATP-dependent efflux pumps, the CIP uptake increased significantly, reaching approximately the same level as that of the susceptible strain. Similar results were obtained with EtBr uptake and efflux experiments. Our data suggest the presence of an active efflux system, possibly an ABC-type efflux pump, implicated in the resistance to CIP and unrelated compounds like EtBr in the human mycoplasma M. hominis .
dc.language.isoENen_US
dc.sourcecrossref
dc.sourceoadoi_repo
dc.sourcebase
dc.sourceresearchgate
dc.title.enEvidence of Active Efflux in Resistance to Ciprofloxacin and to Ethidium Bromide by Mycoplasma hominis
dc.typeArticle de revueen_US
dc.identifier.doi10.1128/aac.46.3.672-679.2002en_US
dc.subject.halSciences de l'environnementen_US
bordeaux.journalAntimicrobial Agents and Chemotherapyen_US
bordeaux.page672-679en_US
bordeaux.volume46en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamEAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.identifierhal-04546400
hal.version1
hal.date.transferred2024-04-15T09:07:21Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Antimicrobial%20Agents%20and%20Chemotherapy&rft.date=2002-03-01&rft.volume=46&rft.issue=3&rft.spage=672-679&rft.epage=672-679&rft.eissn=0066-4804&rft.issn=0066-4804&rft.au=RAHERISON-SEMJEN,%20Chantal&GONZALEZ,%20Patrice&RENAUDIN,%20H.&CHARRON,%20A.&BEBEAR,%20Cecile&rft.genre=article


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