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Specific Effects of Dietary Methylmercury and Inorganic Mercury in Zebrafish (Danio rerio) Determined by Genetic, Histological, and Metallothionein Responses

dc.rights.licenseopenen_US
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorGENTES, Sophie
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorMAURY-BRACHET, Regine
dc.contributor.authorFENG, Caiyan
dc.contributor.authorPEDRERO, Zoyne
dc.contributor.authorTESSIER, Emmanuel
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorLEGEAY, Alexia
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorMESMER-DUDONS, Nathalie
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBAUDRIMONT, Magalie
IDREF: 105696722
dc.contributor.authorMAURICE, Laurence
dc.contributor.authorAMOUROUX, David
dc.contributor.authorGONZALEZ, Patrice
ORCID: 0000-0003-2628-2993
IDREF: 14341917X
dc.date.accessioned2024-04-12T07:54:42Z
dc.date.available2024-04-12T07:54:42Z
dc.date.issued2015-10-28
dc.identifier.issn0013-936Xen_US
dc.identifier.urihttps://www.researchgate.net/publication/283305679_Specific_Effects_of_Dietary_Methylmercury_and_Inorganic_Mercury_in_Zebrafish_Danio_rerio_Determined_by_Genetic_Histological_and_Metallothionein_Responses
dc.identifier.urioai:crossref.org:10.1021/acs.est.5b03586
dc.identifier.uriorcid:0000-0003-3482-3892:10.1021/acs.est.5b03586
dc.identifier.urioadoi:http://www.documentation.ird.fr/hor/fdi:010066026
dc.identifier.urioai:researchgate.net:283305679
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/197570
dc.description.abstractEnA multidisciplinary approach is proposed here to compare toxicity mechanisms of methylmercury (MeHg) and inorganic mercury (iHg) in muscle, liver, and brain from zebrafish (Danio rerio). Animals were dietary exposed to (1) 50 ng Hg g−1, 80% as MeHg; (2) diet enriched in MeHg 10000 ng Hg g−1, 95% as MeHg; (3) diet enriched in iHg 10000 ng Hg g−1, 99% as iHg, for two months. Hg species specific bioaccumulation pathways were highlighted, with a preferential bioaccumulation of MeHg in brain and iHg in liver. In the same way, differences in genetic pattern were observed for both Hg species, (an early genetic response (7 days) for both species in the three organs and a late genetic response (62 days) for iHg) and revealed a dissimilar metabolization of both Hg species. Among the 18 studied genes involved in key metabolic pathways of the cell, major genetic responses were observed in muscle. Electron microscopy revealed damage mainly because of MeHg in muscle and also in liver tissue. In brain, high MeHg and iHg concentrations induced metallothionein production. Finally, the importance of the fish origin in ecotoxicological studies, here the seventh descent of a zebrafish line, is discussed.
dc.language.isoENen_US
dc.sourcecrossref
dc.sourceorcid
dc.sourceoadoi_repo
dc.sourceresearchgate
dc.title.enSpecific Effects of Dietary Methylmercury and Inorganic Mercury in Zebrafish (Danio rerio) Determined by Genetic, Histological, and Metallothionein Responses
dc.typeArticle de revueen_US
dc.identifier.doi10.1021/acs.est.5b03586en_US
dc.subject.halSciences de l'environnementen_US
bordeaux.journalEnvironmental Science and Technologyen_US
bordeaux.page14560-14569en_US
bordeaux.volume49en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.issue24en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamEAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Science%20and%20Technology&rft.date=2015-10-28&rft.volume=49&rft.issue=24&rft.spage=14560-14569&rft.epage=14560-14569&rft.eissn=0013-936X&rft.issn=0013-936X&rft.au=GENTES,%20Sophie&MAURY-BRACHET,%20Regine&FENG,%20Caiyan&PEDRERO,%20Zoyne&TESSIER,%20Emmanuel&rft.genre=article


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