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How to survive the mutational meltdown: lessons from plant RNA viruses

hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorLAFFORGUE, Guillaume
hal.structure.identifierBiologie du fruit et pathologie [BFP]
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorLEFEBVRE, Marie
hal.structure.identifierBiologie du fruit et pathologie [BFP]
hal.structure.identifierInstitut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement [INRAE]
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorMICHON, Thierry
hal.structure.identifierInstituto de Biología Integrativa de Sistemas (I2SysBio), Consejo Superior de Investigaciones Científicas – Universitat de València, Paterna, 46980 València, Spain [CSIC]
dc.contributor.authorELENA, Santiago
dc.date.issued2024-02-12
dc.identifier.issn2551-668X
dc.description.abstractEnMuller's ratchet refers to the irreversible accumulation of deleterious mutations in small populations, resulting in a decline in overall fitness. This phenomenon has been extensively observed in experiments involving microorganisms, including bacteriophages and yeast. While the impact of Muller’s ratchet on viruses has been largely studied in bacteriophages and animal RNA viruses, its effects on plant RNA viruses remain poorly documented. Plant RNA viruses give rise to large and diverse populations that undergo significant bottlenecks during the colonization of distant tissues or through vector-mediated horizontal transmission. In this study, we aim to investigate the role of bottleneck size, the maximum population size between consecutive bottlenecks, and the generation of genetic diversity in countering the effects of Muller’s ratchet. We observed three distinct evolutionary outcomes for tobacco etch virus under three different demographic conditions: (i) a decline in fitness following periodic severe bottlenecks in Chenopodium quinoa, (ii) a consistent fitness level with moderate bottlenecks in C. quinoa, and (iii) a net increase in fitness when severe bottlenecks in C. quinoa were alternated with large population expansions in Nicotiana tabacum. By fitting empirical data to an in silico simulation model, we found that initiating a lesion in C. quinoa required only 1-5 virions, and approximately 40 new virions were produced per lesion. These findings demonstrate that Muller's ratchet can be halted not only by increasing the number of founder viruses but also by incorporating phases of exponential growth to large populations between bottlenecks. Such population expansions generate genetic diversity, serving as a buffer against, and potentially even leveraging, the effects of genetic drift.
dc.language.isoen
dc.publisherPeer Community In
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.title.enHow to survive the mutational meltdown: lessons from plant RNA viruses
dc.typeArticle de revue
dc.identifier.doi10.24072/pci.evolbiol.100702
dc.subject.halSciences du Vivant [q-bio]/Biologie végétale/Phytopathologie et phytopharmacie
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie/Virologie
bordeaux.journalPeer Community In Evolutionary Biology
bordeaux.pagee22
bordeaux.volume4
bordeaux.peerReviewedoui
hal.identifierhal-04512813
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04512813v1
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