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Assessment of Lemna minor (duckweed) and Corbicula fluminea (freshwater clam) as potential indicators of contaminated aquatic ecosystems: responses to presence of psychoactive drug mixtures

dc.rights.licenseopenen_US
hal.structure.identifierBiochimie et Toxicologie des Substances Bioactives [BTSB]
hal.structure.identifierEcole Nationale d'Agriculture de Meknès [ENA]
dc.contributor.authorBOURIOUG, Mohamed
hal.structure.identifierBiochimie et Toxicologie des Substances Bioactives [BTSB]
dc.contributor.authorMAZZITELLI, Jean-Yves
hal.structure.identifierBiochimie et Toxicologie des Substances Bioactives [BTSB]
dc.contributor.authorMARTY, Pierre
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBUDZINSKI, Hélène
ORCID: 0000-0003-1028-9154
IDREF: 070478090
hal.structure.identifierLaboratoire Chrono-environnement (UMR 6249) [LCE]
dc.contributor.authorALEYA, Lotfi
hal.structure.identifierBiochimie et Toxicologie des Substances Bioactives [BTSB]
dc.contributor.authorBONNAFÉ, Elsa
hal.structure.identifierBiochimie et Toxicologie des Substances Bioactives [BTSB]
dc.contributor.authorGERET, Florence
dc.date.accessioned2024-04-11T08:42:47Z
dc.date.available2024-04-11T08:42:47Z
dc.date.issued2018-04
dc.identifier.issn0944-1344en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/197516
dc.description.abstractEnThe pharmaceutical products are emerging pollutants continuously released into the environment, because they cannot be effectively removed by the wastewater treatment plants. In recent years, questions have been raised concerning the environmental risks related to these pollutants. The goal of this research was to evaluate the responses in Lemna minor after 7 days and in Corbicula fluminea after differing durations (1, 3, 7, and 19 days) of exposure to the psychoactive drug mixture (valproic acid, citalopram, carbamazepine, cyamemazine, hydroxyzine, oxazepam, norfluoxetine, lorazepam, fluoxetine, and sertraline) in different concentrations (0, 0 + ethanol, drug concentration (DC) 1 = river water concentration, DC2 = effluent concentration, and DC3 = 10× effluent concentration). In this aim, growth parameters of L. minor, gluthathione S-transferase (GSTs), catalase (CAT), ethoxyresorufin-O-deethylase (EROD) and/or gene expressions (pi-gst, cat, cytochrome P450 4 (cyp4), multidrug resistant 1 (mdr1), and superoxide dismutase (sod)) were measured. GST activities increased significantly in L. minor exposed to DC3, but no changes were found in CAT activity. In C. fluminea, EROD activity was induced significantly in both gill and digestive gland tissues after 3 days’ exposure to DC3, while a GST increase was observed only in digestive gland tissues, suggesting that these pharmaceuticals induced an oxidative effect. Gene expression analysis revealed transient transcriptomic responses of cyp4, sod, and mdr1 under drug concentrations 2 or 3 and no change of expression for the other genes (cat and pi-gst) or condition (environmental drug concentration) tested. Finally, the data reported in this study represent important ecotoxicological information, confirming that this enzyme family (cyp4, sod, and mdr1) may be considered as a sensible and early indicator of exposure to drugs and emphasizing the involvement of selected genes in detoxification pathways.
dc.language.isoENen_US
dc.subject.enPsychotropic pharmaceuticals
dc.subject.enEmerging contaminants
dc.subject.enDefense mechanisms
dc.subject.enBiomarkers
dc.subject.enGene expression
dc.title.enAssessment of Lemna minor (duckweed) and Corbicula fluminea (freshwater clam) as potential indicators of contaminated aquatic ecosystems: responses to presence of psychoactive drug mixtures
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s11356-017-8447-1en_US
dc.subject.halSciences du Vivant [q-bio]/Toxicologie/Ecotoxicologieen_US
dc.subject.halSciences de l'environnement/Biodiversité et Ecologieen_US
dc.subject.halSciences du Vivant [q-bio]/Sciences pharmaceutiques/Médicamentsen_US
dc.subject.halSciences du Vivant [q-bio]/Génétique/Génétique animaleen_US
bordeaux.journalEnvironmental Science and Pollution Researchen_US
bordeaux.page11192-11204en_US
bordeaux.volume25en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamLPTCen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-01863602
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Science%20and%20Pollution%20Research&rft.date=2018-04&rft.volume=25&rft.issue=12&rft.spage=11192-11204&rft.epage=11192-11204&rft.eissn=0944-1344&rft.issn=0944-1344&rft.au=BOURIOUG,%20Mohamed&MAZZITELLI,%20Jean-Yves&MARTY,%20Pierre&BUDZINSKI,%20H%C3%A9l%C3%A8ne&ALEYA,%20Lotfi&rft.genre=article


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