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Anti-tumor efficacy of hyaluronan-based nanoparticles for the co-delivery of drugs in lung cancer

dc.rights.licenseopen
hal.structure.identifierCancer Targets & Experimental Therapeutics
hal.structure.identifierInstitute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB]
dc.contributor.authorJEANNOT, Victor
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorGAUCHE, Cony
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorMAZZAFERRO, Silvia
hal.structure.identifierCancer Targets & Experimental Therapeutics
hal.structure.identifierInstitute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB]
dc.contributor.authorCOUVET, Morgane
hal.structure.identifierCancer Targets & Experimental Therapeutics
hal.structure.identifierInstitute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB]
dc.contributor.authorVANWONTERGHEM, Laetitia
hal.structure.identifierCancer Targets & Experimental Therapeutics
hal.structure.identifierInstitute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB]
dc.contributor.authorHENRY, Maxime
hal.structure.identifierCancer Targets & Experimental Therapeutics
hal.structure.identifierInstitute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB]
dc.contributor.authorDIDIER, Chloé
hal.structure.identifierCancer Targets & Experimental Therapeutics
hal.structure.identifierInstitute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB]
dc.contributor.authorVOLLAIRE, Julien
hal.structure.identifierCancer Targets & Experimental Therapeutics
hal.structure.identifierInstitute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB]
dc.contributor.authorJOSSERAND, Veronique
hal.structure.identifierCancer Targets & Experimental Therapeutics
hal.structure.identifierInstitute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB]
dc.contributor.authorCOLL, Jean-Luc
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSCHATZ, Christophe
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierCancer Targets & Experimental Therapeutics
hal.structure.identifierInstitute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB]
dc.contributor.authorHURBIN, Amandine
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2018
dc.identifier.issn0168-3659
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19750
dc.description.abstractEnCombinations of therapeutic agents could synergistically enhance the response of lung cancer cells. Co-delivery systems capable of transporting chemotherapeutics with different physicochemical properties and with the simultaneous release of drugs remain elusive. Here, we assess the ability of nanoparticles of 30-nm diameter obtained from the self-assembly of hyaluronan-based copolymer targeting CD44 receptors to encapsulate both gefitinib and vorinostat for effective combinational lung cancer treatment. Drug loading was performed by nanoprecipitation. Drug release experiments showed a slow release of both drugs after 5 days. Using two- and three-dimensional lung adenocarcinoma cell cultures, we observed that the nanoparticles were mostly found at the periphery of the CD44-expressing spheroids. These drug-loaded nanoparticles were as cytotoxic as free drugs in the two- and three-dimensional systems and toxicity was due to apoptosis induction. In mouse models, intravenous injection of hyaluronan-based nanoparticles showed a selective delivery to subcutaneous CD44-overexpressing tumors, despite a significant liver capture. In addition, the systemic toxicity of the free drugs was reduced by their co-delivery using the nanoparticles. Finally, intrapulmonary administration of drug-loaded nanoparticles, to avoid a possible hepatic toxicity due to their accumulation in the liver, showed a stronger inhibition of orthotopic lung tumor growth compared to free drugs. In conclusion, hyaluronan-based nanoparticles provide active targeting partially mediated by CD44, less-toxic drug release and improved antitumor efficiency.
dc.language.isoen
dc.publisherElsevier
dc.subject.enDrug co-delivery
dc.subject.enPolymer nanoparticles
dc.subject.enSpheroids
dc.subject.enLung cancer
dc.subject.enGefitinib
dc.subject.enVorinostat
dc.title.enAnti-tumor efficacy of hyaluronan-based nanoparticles for the co-delivery of drugs in lung cancer
dc.typeArticle de revue
dc.identifier.doi10.1016/j.jconrel.2018.02.024
dc.subject.halSciences du Vivant [q-bio]/Sciences pharmaceutiques/Médicaments
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale/Biomatériaux
dc.subject.halSciences du Vivant [q-bio]/Cancer
bordeaux.journalJournal of Controlled Release
bordeaux.page117-128
bordeaux.volume275
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-02151669
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02151669v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Controlled%20Release&rft.date=2018&rft.volume=275&rft.spage=117-128&rft.epage=117-128&rft.eissn=0168-3659&rft.issn=0168-3659&rft.au=JEANNOT,%20Victor&GAUCHE,%20Cony&MAZZAFERRO,%20Silvia&COUVET,%20Morgane&VANWONTERGHEM,%20Laetitia&rft.genre=article


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