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Targeting CD44 receptor-positive lung tumors using polysaccharide-based nanocarriers: Influence of nanoparticle size and administration route

dc.rights.licenseopen
hal.structure.identifierInstitut d'oncologie/développement Albert Bonniot de Grenoble [INSERM U823]
dc.contributor.authorJEANNOT, Victor
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorMAZZAFERRO, Silvia
hal.structure.identifierOPTIMAL
hal.structure.identifierInstitut d'oncologie/développement Albert Bonniot de Grenoble [INSERM U823]
dc.contributor.authorLAVAUD, Jonathan
hal.structure.identifierInstitut d'oncologie/développement Albert Bonniot de Grenoble [INSERM U823]
dc.contributor.authorVANWONTERGHEM, Laetitia
hal.structure.identifierOPTIMAL
hal.structure.identifierInstitut d'oncologie/développement Albert Bonniot de Grenoble [INSERM U823]
dc.contributor.authorHENRY, Maxime
hal.structure.identifierInstitut d'oncologie/développement Albert Bonniot de Grenoble [INSERM U823]
dc.contributor.authorARBOLEAS, Melanie
hal.structure.identifierOPTIMAL
hal.structure.identifierInstitut d'oncologie/développement Albert Bonniot de Grenoble [INSERM U823]
dc.contributor.authorVOLLAIRE, Julien
hal.structure.identifierOPTIMAL
hal.structure.identifierInstitut d'oncologie/développement Albert Bonniot de Grenoble [INSERM U823]
dc.contributor.authorJOSSERAND, Veronique
hal.structure.identifierInstitut d'oncologie/développement Albert Bonniot de Grenoble [INSERM U823]
dc.contributor.authorCOLL, Jean-Luc
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSCHATZ, Christophe
hal.structure.identifierInstitut d'oncologie/développement Albert Bonniot de Grenoble [INSERM U823]
dc.contributor.authorHURBIN, Amandine
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2016
dc.identifier.issn1549-9634
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19749
dc.description.abstractEnNew approaches that are more efficient and able to specifically reach lung tumors are needed. We developed new hyaluronan-based nanoparticles targeting CD44 receptors of two different sizes and compared their lung cancer cells targeting efficacy in vitro and in vivo. The nanoparticles' cellular uptake was dose-dependent, and specific to hyaluronan receptors, particularly CD44. The binding and internalization differed according to nanoparticle size. In vivo biodistribution studies in two orthotopic lung tumor models showed that intrapulmonary nebulized nanoparticles accumulated in lungs, but not in the tumor nodules. In contrast, despite a significant liver capture, intravenous injection led to a better accumulation of the nanoparticles in the lung tumors compared with the surrounding healthy lung tissues. We demonstrated that the hyaluronan-based nanoparticles size plays significant role in cellular uptake and biodistribution. Small nanoparticles showed active targeting of CD44-overexpressing tumors, suggesting that they could be used as drug-delivery system. From the Clinical Editor: Combating cancers remains an important goal in clinical medicine. In this study, the authors investigated the ability of two hyaluronan-based nanoparticles targeting CD44 receptors to home in on lung cancer cells in an in-vivo orthotropic model. The preferential uptake of smaller sized nanoparticles via intravenous route has further enhanced the existing knowledge of future drug designs
dc.language.isoen
dc.publisherElsevier
dc.subject.enLung cancer
dc.subject.enNear-infrared optical imaging
dc.subject.enBiodistribution
dc.subject.enCD44
dc.subject.enPolymer nanoparticles
dc.subject.enHyaluronan
dc.title.enTargeting CD44 receptor-positive lung tumors using polysaccharide-based nanocarriers: Influence of nanoparticle size and administration route
dc.typeArticle de revue
dc.identifier.doi10.1016/j.nano.2015.11.018
dc.subject.halSciences du Vivant [q-bio]/Biotechnologies
dc.subject.halSciences du Vivant [q-bio]/Cancer
bordeaux.journalNanomedicine: Nanotechnology, Biology and Medicine
bordeaux.page921-932
bordeaux.volume12
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue4
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01360462
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01360462v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nanomedicine:%20Nanotechnology,%20Biology%20and%20Medicine&rft.date=2016&rft.volume=12&rft.issue=4&rft.spage=921-932&rft.epage=921-932&rft.eissn=1549-9634&rft.issn=1549-9634&rft.au=JEANNOT,%20Victor&MAZZAFERRO,%20Silvia&LAVAUD,%20Jonathan&VANWONTERGHEM,%20Laetitia&HENRY,%20Maxime&rft.genre=article


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