Hyaluronic acid presentation at the surface of self‐assembled nanoparticles transforms a hyaluronidase HYAL1 substrate into an efficient and selective inhibitor
dc.rights.license | open | |
hal.structure.identifier | L'Oréal Recherche France [L'Oréal Recherche] | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | DUAN, Haohao | |
hal.structure.identifier | L'Oréal Recherche France [L'Oréal Recherche] | |
dc.contributor.author | DONOVAN, Mark | |
hal.structure.identifier | L'Oréal Recherche France [L'Oréal Recherche] | |
dc.contributor.author | HERNANDEZ, Franck | |
hal.structure.identifier | ARN : régulations naturelle et artificielle | |
dc.contributor.author | DI PRIMO, Carmelo | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | GARANGER, Elisabeth
IDREF: 089451740 | |
hal.structure.identifier | L'Oréal Recherche France [L'Oréal Recherche] | |
dc.contributor.author | SCHULTZE, Xavier | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | LECOMMANDOUX, Sebastien | |
dc.date.accessioned | 2020 | |
dc.date.available | 2020 | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1433-7851 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/19650 | |
dc.description.abstractEn | In this study, an original method of macromolecular design was used to develop a hyaluronidase‐1 (HYAL1) inhibitor from its principal substrate, hyaluronic acid (HA). HA‐based nanoparticles (HA‐NP) were obtained by copolymer self‐assembly and their effects on HYAL1 activity were investigated by combining different analytical tools. Compared to HA, HA‐NP exhibited an enhanced stability against HYAL1 degradation while maintaining its interaction with HA receptors CD44 and aggrecan. HA‐NP displayed a strong and selective inhibition of HYAL1 activity and retarded the hydrolysis of higher molar mass HA in solution. A co‐nanoprecipitation process was used to formulate a range of hybrid nanoparticle samples, which demonstrated the specificity and efficiency of HA‐NP in HYAL1 inhibition. | |
dc.language.iso | en | |
dc.publisher | Wiley-VCH Verlag | |
dc.subject.en | self-assembly | |
dc.subject.en | Surface plasmon resonance | |
dc.subject.en | block copolymer | |
dc.subject.en | hyaluronan | |
dc.subject.en | targeting | |
dc.subject.en | receptor inhibition | |
dc.subject.en | Hyaluronic acid | |
dc.subject.en | Hyaluronidase | |
dc.subject.en | Polymer nanoparticles | |
dc.title.en | Hyaluronic acid presentation at the surface of self‐assembled nanoparticles transforms a hyaluronidase HYAL1 substrate into an efficient and selective inhibitor | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1002/anie.202005212 | |
dc.subject.hal | Chimie/Polymères | |
dc.subject.hal | Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft] | |
dc.subject.hal | Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biochimie [q-bio.BM] | |
bordeaux.journal | Angewandte Chemie International Edition | |
bordeaux.page | 13591-13596 | |
bordeaux.volume | 59 | |
bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
bordeaux.issue | 32 | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-02561770 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-02561770v1 | |
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