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The Zebra Mussel (Dreissena polymorpha) as a Model Organism for Ecotoxicological Studies: A Prior 1H NMR Spectrum Interpretation of a Whole Body Extract for Metabolism Monitoring
| dc.rights.license | open | en_US |
| hal.structure.identifier | Stress Environnementaux et BIOsurveillance des milieux aquatiques [SEBIO] | |
| hal.structure.identifier | Laboratoire Interdisciplinaire des Environnements Continentaux [LIEC] | |
| dc.contributor.author | PRUD’HOMME, Sophie Martine | |
| hal.structure.identifier | Stress Environnementaux et BIOsurveillance des milieux aquatiques [SEBIO] | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | HANI, Younes Mohamed Ismail | |
| hal.structure.identifier | Toulouse Biotechnology Institute [TBI] | |
| dc.contributor.author | COX, Neil | |
| hal.structure.identifier | Toulouse Biotechnology Institute [TBI] | |
| dc.contributor.author | LIPPENS, Guy | |
| hal.structure.identifier | Institut de Chimie Moléculaire de Reims - UMR 7312 [ICMR] | |
| dc.contributor.author | NUZILLARD, Jean-Marc | |
| hal.structure.identifier | Stress Environnementaux et BIOsurveillance des milieux aquatiques [SEBIO] | |
| dc.contributor.author | GEFFARD, Alain | |
| dc.date.accessioned | 2024-04-08T12:03:09Z | |
| dc.date.available | 2024-04-08T12:03:09Z | |
| dc.date.issued | 2020 | |
| dc.identifier.issn | 2218-1989 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/196248 | |
| dc.description.abstractEn | The zebra mussel (Dreissena polymorpha) represents a useful reference organism for the ecotoxicological study of inland waters, especially for the characterization of the disturbances induced by human activities. A nuclear magnetic resonance (NMR)-based metabolomic approach was developed on this species. The investigation of its informative potential required the prior interpretation of a reference 1 H NMR spectrum of a lipid-free zebra mussel extract. After the extraction of polar metabolites from a pool of whole-body D. polymorpha powder, the resulting highly complex 1D 1 H NMR spectrum was interpreted and annotated through the analysis of the corresponding 2D homonuclear and heteronuclear NMR spectra. The spectrum interpretation was completed and validated by means of sample spiking with 24 commercial compounds. Among the 238 detected 1 H signals, 53% were assigned, resulting in the identification of 37 metabolites with certainty or high confidence, while 5 metabolites were only putatively identified. The description of such a reference spectrum and its annotation are expected to speed up future analyses and interpretations of NMR-based metabolomic studies on D. polymorpha and to facilitate further explorations of the impact of environmental changes on its physiological state, more particularly in the context of large-scale ecological and ecotoxicological studies. | |
| dc.language.iso | EN | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nd/ | |
| dc.subject.en | Dreissena polymorpha | |
| dc.subject.en | zebra mussel | |
| dc.subject.en | NMR | |
| dc.subject.en | metabolomics | |
| dc.subject.en | annotation | |
| dc.subject.en | ecotoxicology | |
| dc.title.en | The Zebra Mussel (Dreissena polymorpha) as a Model Organism for Ecotoxicological Studies: A Prior 1H NMR Spectrum Interpretation of a Whole Body Extract for Metabolism Monitoring | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/metabo10060256 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biologie animale/Zoologie des invertébrés | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Toxicologie/Ecotoxicologie | en_US |
| bordeaux.journal | Metabolites | en_US |
| bordeaux.page | 256 | en_US |
| bordeaux.volume | 10 | en_US |
| bordeaux.hal.laboratories | EPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805 | en_US |
| bordeaux.issue | 6 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.team | EA | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-02934872 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | CC BY-ND | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Metabolites&rft.date=2020&rft.volume=10&rft.issue=6&rft.spage=256&rft.epage=256&rft.eissn=2218-1989&rft.issn=2218-1989&rft.au=PRUD%E2%80%99HOMME,%20Sophie%20Martine&HANI,%20Younes%20Mohamed%20Ismail&COX,%20Neil&LIPPENS,%20Guy&NUZILLARD,%20Jean-Marc&rft.genre=article |
