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Self-Assembling Peptide—Polymer Nano-Objects via Polymerization-Induced Self-Assembly

dc.rights.licenseopen
hal.structure.identifierInstitut Européen des membranes [IEM]
dc.contributor.authorDAO, Tuyen
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorVEZENKOV, Lubomir
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorSUBRA, Gilles
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorAMBLARD, Muriel
hal.structure.identifierLaboratoire Charles Coulomb [L2C]
dc.contributor.authorIN, Martin
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLE MEINS, Jean-Francois
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorAUBRIT, Florian
hal.structure.identifierEindhoven University of Technology [Eindhoven] [TU/e]
dc.contributor.authorMORADI, Mohammad-Amin
hal.structure.identifierInstitut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier [ICGM ICMMM]
dc.contributor.authorLADMIRAL, Vincent
hal.structure.identifierInstitut Européen des membranes [IEM]
dc.contributor.authorSEMSARILAR, Mona
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2020
dc.identifier.issn0024-9297
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19623
dc.description.abstractEnSelf-assembling peptides (SAPs) have been extensively studied for their ability to form nanoscale ordered structures driven by noncovalent molecular interactions. Meanwhile, polymerization-induced self-assembly (PISA) has been exploited as a facile and efficient way to produce various amphiphilic block copolymer nano-objects, whose self-assembly was governed predominantly by the interactions of the different blocks with the polymerization medium. In this work, we combined PISA with SAPs to prepare novel peptide–polymer hybrid nano-objects, thus harnessing the advantages of PISA and the self-assembling driving force of SAPs. A tripeptide methacrylamide derivative (MAm-Gly-Phe-Phe-NH2, denoted as MAm-GFF, where MAm means methacrylamide) was copolymerized with glycerol monomethacrylate (GMA) to produce a P(GMA65-stat-(MAm-GFF)7) macro-chain transfer agent (macro-CTA) by reversible addition–fragmentation chain transfer polymerization in dimethylformamide. This peptide-based macro-CTA was then successfully chain-extended with poly(2-hydroxypropyl methacrylate) (PHPMA) by aqueous dispersion PISA, forming P(GMA65-stat-(MAm-GFF)7)-b-PHPMA28 self-assembled objects. Fibrous structures were observed by transmission electron microscopy (TEM) and Cryo-TEM, in agreement with depolarized dynamic light scattering, static light scattering, and small-angle X-ray scattering experiments that also revealed long anisotropic morphologies. Such structures have not been reported previously for PISA-prepared nano-objects. This confirms the decisive influence of the GFF SAP on the self-assembly. In addition, annealing the PISA suspension at different temperatures led to a significant size decrease in the self-assembled objects and to a morphological transition caused by the thermosensitivity of both the core-forming PHPMA block and the stabilizing P(GMA-stat-(MAm-GFF)) block.
dc.description.sponsorshipChimie des systèmes moléculaires et interfaciaux - ANR-10-LABX-05-01
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subject.enRAFT polymerization
dc.subject.enPeptides and proteins
dc.subject.enCopolymerization
dc.subject.enCopolymers
dc.subject.enTransmission electron microscopy TEM
dc.subject.enSmall angle X-ray scattering SAXS
dc.subject.enDepolarized dynamic light scattering DDLS
dc.title.enSelf-Assembling Peptide—Polymer Nano-Objects via Polymerization-Induced Self-Assembly
dc.typeArticle de revue
dc.identifier.doi10.1021/acs.macromol.0c01260
dc.subject.halChimie/Polymères
dc.subject.halChimie/Matériaux
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
dc.description.sponsorshipEuropeFlexible Magnetic Filaments
bordeaux.journalMacromolecules
bordeaux.page7034-7043
bordeaux.volume53
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue16
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-02915614
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02915614v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Macromolecules&rft.date=2020&rft.volume=53&rft.issue=16&rft.spage=7034-7043&rft.epage=7034-7043&rft.eissn=0024-9297&rft.issn=0024-9297&rft.au=DAO,%20Tuyen&VEZENKOV,%20Lubomir&SUBRA,%20Gilles&AMBLARD,%20Muriel&IN,%20Martin&rft.genre=article


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