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Modeling the respiratory chain complexes with biothermokinetic equations - The case of complex I.

hal.structure.identifierPhysiopathologie mitochondriale
dc.contributor.authorHEISKE, Margit
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorNAZARET, Christine
hal.structure.identifierPhysiopathologie mitochondriale
dc.contributor.authorMAZAT, Jean-Pierre
dc.date.accessioned2024-04-04T03:20:53Z
dc.date.available2024-04-04T03:20:53Z
dc.date.issued2014-07-24
dc.identifier.issn0006-3002
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/194621
dc.description.abstractEn: The mitochondrial respiratory chain plays a crucial role in energy metabolism and its dysfunction is implicated in a wide range of human diseases. In order to understand the global expression of local mutations in the rate of oxygen consumption or in the production of adenosine triphosphate (ATP) it is useful to have a mathematical model in which the changes in a given respiratory complex are properly modeled. Our aim in this paper is to provide thermodynamics respecting and structurally simple equations to represent the kinetics of each isolated complexes which can, assembled in a dynamical system, also simulate the behavior of the respiratory chain, as a whole, under a large set of different physiological and pathological conditions. On the example of the reduced nicotinamide adenine dinucleotide (NADH)-ubiquinol-oxidoreductase (complex I) we analyze the suitability of different types of rate equations. Based on our kinetic experiments we show that very simple rate laws, as those often used in many respiratory chain models, fail to describe the kinetic behavior when applied to a wide concentration range. This led us to adapt rate equations containing the essential parameters of enzyme kinetic, maximal velocities and Henri-Michaelis-Menten like-constants (KM and KI) to satisfactorily simulate these data.
dc.language.isoen
dc.publisherElsevier
dc.title.enModeling the respiratory chain complexes with biothermokinetic equations - The case of complex I.
dc.typeArticle de revue
dc.identifier.doi10.1016/j.bbabio.2014.07.013
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalBBA - Biochimica et Biophysica Acta
bordeaux.page1707-1716
bordeaux.volume1837
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue10
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01058822
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01058822v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BBA%20-%20Biochimica%20et%20Biophysica%20Acta&rft.date=2014-07-24&rft.volume=1837&rft.issue=10&rft.spage=1707-1716&rft.epage=1707-1716&rft.eissn=0006-3002&rft.issn=0006-3002&rft.au=HEISKE,%20Margit&NAZARET,%20Christine&MAZAT,%20Jean-Pierre&rft.genre=article


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