Afficher la notice abrégée

Transcriptome profile analysis reveals specific signatures of pollutants in Atlantic eels

hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBAILLON, Lucie
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorPIERRON, Fabien
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierQuality control and dynamic reliability [CQFD]
dc.contributor.authorCOUDRET, Raphaël
hal.structure.identifierDépartement de Biologie [Québec]
dc.contributor.authorNORMENDEAU, Eric
hal.structure.identifierCentre Eau Terre Environnement [Québec] [INRS - ETE]
dc.contributor.authorCARON, Antoine
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorPELUHET, Laurent
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorLABADIE, Pierre
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBUDZINSKI, Hélène
hal.structure.identifierLaboratoire de Mathématiques de Bretagne Atlantique [LMBA]
dc.contributor.authorDURRIEU, Gilles
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierQuality control and dynamic reliability [CQFD]
dc.contributor.authorSARACCO, Jérôme
hal.structure.identifierEcosystèmes aquatiques et changements globaux [UR EABX]
dc.contributor.authorELIE, Pierre
hal.structure.identifierCentre Eau Terre Environnement [Québec] [INRS - ETE]
dc.contributor.authorCOUTURE, Patrice
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBAUDRIMONT, Magalie
hal.structure.identifierDépartement de Biologie [Québec]
dc.contributor.authorBERNATHEZ, Louis
dc.date.accessioned2024-04-04T03:20:26Z
dc.date.available2024-04-04T03:20:26Z
dc.date.created2014-09-19
dc.date.issued2014-09-19
dc.identifier.issn0963-9292
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/194588
dc.description.abstractEnIdentifying specific effects of contaminants in a multi-stress field context remain a challenge in ecotoxicology. In this context, "omics" technologies, by allowing the simultaneous measurement of numerous biological endpoints, could help unravel the in situ toxicity of contaminants. In this study, wild Atlantic eels were sampled in 8 sites presenting a broad contamination gradient in France and Canada. The global hepatic transcriptome of animals was determined by RNA-Seq. In parallel, the contamination level of fish to 8 metals and 25 organic pollutants was determined. Factor analysis for multiple testing was used to identify genes that are most likely to be related to a single factor. Among the variables analyzed, arsenic (As), cadmium (Cd), lindane (γ-HCH) and the hepato-somatic index (HSI) were found to be the main factors affecting eel's transcriptome. Genes associated with As exposure were involved in the mechanisms that have been described during As vasculotoxicity in mammals. Genes correlated with Cd were involved in cell cycle and energy metabolism. For γ-HCH, genes were involved in lipolysis and cell growth. Genes associated with HSI were involved in protein, lipid and iron metabolisms. Our study proposes specific gene signatures of pollutants and their impacts in fish exposed to multi-stress conditions.
dc.description.sponsorshipImpacts des contaminations métalliques et organiques des systèmes de la Gironde et du St Laurent sur deux espèces en déclin, l'anguille européenne et américaine. - ANR-10-INTB-1704
dc.language.isoen
dc.publisherSpringer Verlag
dc.title.enTranscriptome profile analysis reveals specific signatures of pollutants in Atlantic eels
dc.typeArticle de revue
dc.identifier.doi10.1007/s10646-014-1356-x
dc.subject.halStatistiques [stat]/Applications [stat.AP]
bordeaux.journalEcotoxicology
bordeaux.page71-84
bordeaux.volume24
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue1
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01068022
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01068022v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Ecotoxicology&rft.date=2014-09-19&rft.volume=24&rft.issue=1&rft.spage=71-84&rft.epage=71-84&rft.eissn=0963-9292&rft.issn=0963-9292&rft.au=BAILLON,%20Lucie&PIERRON,%20Fabien&COUDRET,%20Rapha%C3%ABl&NORMENDEAU,%20Eric&CARON,%20Antoine&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée