Afficher la notice abrégée

hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorLABARTHE, Simon
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorBAYER, Jason
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorCOUDIÈRE, Yves
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorHENRY, Jacques
hal.structure.identifierIHU-LIRYC
hal.structure.identifierHôpital Haut-Lévêque
dc.contributor.authorCOCHET, Hubert
hal.structure.identifierHôpital Haut-Lévêque
hal.structure.identifierIHU-LIRYC
dc.contributor.authorJAIS, Pierre
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorVIGMOND, Edward
dc.date.accessioned2024-04-04T03:18:47Z
dc.date.available2024-04-04T03:18:47Z
dc.date.issued2014-12
dc.identifier.issn1099-5129
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/194445
dc.description.abstractEn(1) Aims: Atrial numerical modelling has generally represented the organ as either a surface or tissue with thickness. While surface models have significant computational advantages over tissue models, they cannot fully capture propagation patterns seen in vivo, such as dissociation of activity between endo-and epicardium. We introduce an intermediate representation, a bilayer model of the human atria, which is capable of recreating recorded activation patterns. (2) Methods: We simultaneously solved two surface monodomain problems by formalizing an optimization method to set a coupling coefficient between them. Two different asymptotically equivalent numerical implementations of the model are presented. We then built a geometrically and electrophysiologically detailed model of the human atria based on CT data, including two layers of fibre directions, major muscle bundles, and discrete atrial coupling. We adjusted parameters to recreate clinically measured activation times. Activation was compared to a monolayer model. (3) Results: Activation was fit to the physiological range measured over the entire atria. The crista terminalis and pectinate muscles were important for local right atrial activation, but did not significantly affect total activation time. Propagation in the bilayer model was similar to that of a monolayer, but with noticeable difference, due to three-dimensional propagationwhere fibre direction changed abruptly across the wall, resulting in a slight dissociation of activity. (4) Conclusion: Atrial structure plays the dominant role in determining activation. A bilayer model is able to take into account transmural heterogeneities, while maintaining thelow computational load associated with surface models.
dc.description.sponsorshipL'Institut de Rythmologie et modélisation Cardiaque - ANR-10-IAHU-0004
dc.description.sponsorshipModèles numériques haute résolution de l'électrophysiologie cardiaque - ANR-13-MONU-0004
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.subject.ensurface model
dc.subject.enatrial arrhythmia
dc.subject.entwo-layer model
dc.subject.enhuman atria
dc.subject.enatrial physiology
dc.title.enA bilayer model of human atria: mathematical background, construction, and assessment
dc.typeArticle de revue
dc.identifier.doi10.1093/europace/euu256
dc.subject.halInformatique [cs]/Modélisation et simulation
dc.description.sponsorshipEuropeThe European Network for Translational Research in Atrial Fibrillation
bordeaux.journalEP-Europace
bordeaux.page29
bordeaux.volume16
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issuesuppl 4
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01132905
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01132905v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=EP-Europace&rft.date=2014-12&rft.volume=16&rft.issue=suppl%204&rft.spage=29&rft.epage=29&rft.eissn=1099-5129&rft.issn=1099-5129&rft.au=LABARTHE,%20Simon&BAYER,%20Jason&COUDI%C3%88RE,%20Yves&HENRY,%20Jacques&COCHET,%20Hubert&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée