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Migration and orientation of endothelial cells on micropatterned polymers: A simple model based on classical mechanics

hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorJOIE, Julie
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorLEI, Yifeng
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorDURRIEU, Marie-Christine
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierUniversité de Bordeaux [UB]
hal.structure.identifierModélisation Mathématique pour l'Oncologie [MONC]
dc.contributor.authorCOLIN, Thierry
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation Mathématique pour l'Oncologie [MONC]
dc.contributor.authorPOIGNARD, Clair
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation Mathématique pour l'Oncologie [MONC]
dc.contributor.authorSAUT, Olivier
dc.date.accessioned2024-04-04T03:17:32Z
dc.date.available2024-04-04T03:17:32Z
dc.date.issued2015-06
dc.identifier.issn1531-3492
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/194314
dc.description.abstractEnUnderstanding the endothelial cell migration on micropatterned polymers, as well as the cell orientation is a critical issue in tissue engineering, since it is the preliminary step towards cell polarization and that possibly leads to the blood vessel formation. In this paper, we derive a simple agent-based model to describe the migration and the orientation of endothelial cells seeded on bioactive micropatterned polymers. The aim of the modeling is to provide a simple model that corroborates quantitatively the experiments, without considering the complex phenomena inherent to cell migration. Our model is obtained thanks to a classical mechanics approach based on experimental observations. Even though its simplicity, it provides numerical results that are quantitatively in accordance with the experimental data, and thus our approach can be seen as a preliminary way towards a simple modeling of cell migration.
dc.language.isoen
dc.publisherAmerican Institute of Mathematical Sciences
dc.title.enMigration and orientation of endothelial cells on micropatterned polymers: A simple model based on classical mechanics
dc.typeArticle de revue
dc.identifier.doi10.3934/dcdsb.2015.20.1059
dc.subject.halMathématiques [math]/Equations aux dérivées partielles [math.AP]
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
bordeaux.journalDiscrete and Continuous Dynamical Systems - Series B
bordeaux.volume20
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue4
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01203488
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01203488v1
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