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Optimal target localization for subthalamic stimulation in patients with Parkinson disease

hal.structure.identifierInstitut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]
dc.contributor.authorWELTER, Marie-Laure
hal.structure.identifierInstitut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
dc.contributor.authorSCHÜPBACH, Michael
hal.structure.identifierCentre de Recherche de l'Institut du Cerveau et de la Moelle épinière [CRICM]
dc.contributor.authorCZERNECKI, Virginie
hal.structure.identifierInstitut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]
dc.contributor.authorKARACHI, Carine
hal.structure.identifierCentre de Recherche de l'Institut du Cerveau et de la Moelle épinière [CRICM]
dc.contributor.authorFERNANDEZ-VIDAL, Sara
hal.structure.identifierDépartement de Biostatistiques [Paris]
dc.contributor.authorGOLMARD, Jean-Louis
hal.structure.identifierDipartimento di Scienze della Terra [Cagliari]
dc.contributor.authorSERRA, Giulia
hal.structure.identifierTransformation Intégrée de la Matière Renouvelable [TIMR]
dc.contributor.authorNAVARRO, Soledad
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
dc.contributor.authorWELARATNE, Arlette
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorHARTMANN, Andréas
dc.contributor.authorMESNAGE, Valérie
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
dc.contributor.authorPINEAU, Fanny
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
dc.contributor.authorCORNU, Philippe
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
dc.contributor.authorPIDOUX, Bernard
hal.structure.identifierCIC AP-HP (pitie-Salpetriere)/inserm
dc.contributor.authorWORBE, Yulia
hal.structure.identifierService de neurologie [Poitiers]
hal.structure.identifierHellenic Air Force General Hospital [Athens]
dc.contributor.authorZIKOS, Panayiotis
hal.structure.identifierUniversité Pierre et Marie Curie - Paris 6 [UPMC]
dc.contributor.authorGRABLI, David
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
hal.structure.identifierAlgorithms, models and methods for images and signals of the human brain = Algorithmes, modèles et méthodes pour les images et les signaux du cerveau humain [ICM Paris] [ARAMIS]
dc.contributor.authorGALANAUD, Damien
hal.structure.identifierCentre de recherche sur l'espace sonore et l'environnement urbain [CRESSON]
dc.contributor.authorBONNET, Anne-Marie
hal.structure.identifierLaboratory of Physics of Materials and Nanomaterials Applied at Environment [LaPhyMNE]
dc.contributor.authorBELAID, Hayat
hal.structure.identifierInstitut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]
hal.structure.identifierAlgorithms, models and methods for images and signals of the human brain = Algorithmes, modèles et méthodes pour les images et les signaux du cerveau humain [ICM Paris] [ARAMIS]
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
dc.contributor.authorDORMONT, Didier
hal.structure.identifierInstitut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]
dc.contributor.authorVIDAILHET, Marie
hal.structure.identifierInstitut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]
dc.contributor.authorMALLET, Luc
hal.structure.identifierService de neurologie [Poitiers]
dc.contributor.authorHOUETO, Jean-Luc
hal.structure.identifierPlateforme de neuroimagerie CENIR = Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] [CENIR]
dc.contributor.authorBARDINET, Eric
hal.structure.identifierInstitut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]
dc.contributor.authorYELNIK, Jerome
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
dc.contributor.authorAGID, Yves
dc.date.accessioned2024-04-04T03:16:27Z
dc.date.available2024-04-04T03:16:27Z
dc.date.issued2014-04-15
dc.identifier.issn0028-3878
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/194215
dc.description.abstractEnTo further determine the causes of variable outcome from deep brain stimulation of the subthalamic nucleus (DBS-STN) in patients with Parkinson disease (PD). Data were obtained from our cohort of 309 patients with PD who underwent DBS-STN between 1996 and 2009. We examined the relationship between the 1-year motor, cognitive, and psychiatric outcomes and (1) preoperative PD clinical features, (2) MRI measures, (3) surgical procedure, and (4) locations of therapeutic contacts. Pre- and postoperative results were obtained in 262 patients with PD. The best motor outcome was obtained when stimulating contacts were located within the STN as compared with the zona incerta (64% vs 49% improvement). Eighteen percent of the patients presented a postoperative cognitive decline, which was found to be principally related to the surgical procedure. Other factors predictive of poor cognitive outcome were perioperative confusion and psychosis. Nineteen patients showed a stimulation-induced hypomania, which was related to both the form of the disease (younger age, shorter disease duration, higher levodopa responsiveness) and the ventral contact location. Postoperative depression was more frequent in patients already showing preoperative depressive and/or residual axial motor symptoms. In this homogeneous cohort of patients with PD, we showed that (1) the STN is the best target to improve motor symptoms, (2) postoperative cognitive deficit is mainly related to the surgery itself, and (3) stimulation-induced hypomania is related to a combination of both the disease characteristics and a more ventral STN location.
dc.language.isoen
dc.publisherAmerican Academy of Neurology
dc.subject.meshAged
dc.subject.meshDeep Brain Stimulation
dc.subject.meshParkinson Disease
dc.subject.meshPostoperative Period
dc.subject.meshSubthalamic Nucleus
dc.subject.meshTreatment Outcome
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.title.enOptimal target localization for subthalamic stimulation in patients with Parkinson disease
dc.typeArticle de revue
dc.identifier.doi10.1212/WNL.0000000000000315
dc.subject.halSciences de l'ingénieur [physics]/Traitement du signal et de l'image
dc.subject.halInformatique [cs]/Vision par ordinateur et reconnaissance de formes [cs.CV]
dc.subject.halInformatique [cs]/Imagerie médicale
dc.subject.halInformatique [cs]/Traitement des images
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale/Imagerie
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]/Neurobiologie
bordeaux.journalNeurology
bordeaux.page1352-61
bordeaux.volume82
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue15
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01251658
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01251658v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neurology&rft.date=2014-04-15&rft.volume=82&rft.issue=15&rft.spage=1352-61&rft.epage=1352-61&rft.eissn=0028-3878&rft.issn=0028-3878&rft.au=WELTER,%20Marie-Laure&SCH%C3%9CPBACH,%20Michael&CZERNECKI,%20Virginie&KARACHI,%20Carine&FERNANDEZ-VIDAL,%20Sara&rft.genre=article


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