CORRECTION OF PHOTOBLEACHING FOR THE ASSESSMENT OF PHARMACOKINETIC PARAMETERS USING DYNAMIC FLUORESCENCE MICROSCOPY
| hal.structure.identifier | University Medical Center [Utrecht] [UMCU] | |
| dc.contributor.author | DERIEPPE, Marc | |
| hal.structure.identifier | University Medical Center [Utrecht] [UMCU] | |
| dc.contributor.author | BOS, Clemens | |
| hal.structure.identifier | University Medical Center [Utrecht] [UMCU] | |
| dc.contributor.author | DE GREEF, M. | |
| hal.structure.identifier | University Medical Center [Utrecht] [UMCU] | |
| dc.contributor.author | MOONEN, Chrit | |
| hal.structure.identifier | University Medical Center [Utrecht] [UMCU] | |
| hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
| dc.contributor.author | DENIS DE SENNEVILLE, Baudouin | |
| dc.date.accessioned | 2024-04-04T03:15:57Z | |
| dc.date.available | 2024-04-04T03:15:57Z | |
| dc.date.created | 2015-06-01 | |
| dc.date.issued | 2015-06-01 | |
| dc.date.conference | 2015-05-15 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/194173 | |
| dc.description.abstractEn | Local drug delivery in oncology aims at depositing high doses of anticancer agents while limiting their toxic side effects. Biological barriers, such as cell plasma membranes, hinder their delivery and requires strategies to address this challenge. Previously [1], we demonstrated the feasibility to monitor in real-time, with dynamic fluorescence microscopy, the in-tracellular delivery of a hydrophilic model drug mediated by ultrasound (US), and to quantify the pharmacokinetic parameters derived from a two-compartment model. We evaluate here the impact of the photobleaching (PB) effect experimentally , and compute the PB-corrected uptake kinetics. | |
| dc.language.iso | en | |
| dc.title.en | CORRECTION OF PHOTOBLEACHING FOR THE ASSESSMENT OF PHARMACOKINETIC PARAMETERS USING DYNAMIC FLUORESCENCE MICROSCOPY | |
| dc.type | Communication dans un congrès | |
| dc.subject.hal | Sciences de l'ingénieur [physics]/Traitement du signal et de l'image | |
| bordeaux.hal.laboratories | Institut de Mathématiques de Bordeaux (IMB) - UMR 5251 | * |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | CNRS | |
| bordeaux.conference.title | IEEE International Symposium on Biomedical Imaging (ISBI) | |
| bordeaux.country | US | |
| bordeaux.conference.city | New-York | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-01259351 | |
| hal.version | 1 | |
| hal.invited | non | |
| hal.proceedings | non | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-01259351v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2015-06-01&rft.au=DERIEPPE,%20Marc&BOS,%20Clemens&DE%20GREEF,%20M.&MOONEN,%20Chrit&DENIS%20DE%20SENNEVILLE,%20Baudouin&rft.genre=unknown |
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