Impact of external medium conductivity on cell membrane electropermeabilization by microsecond and nanosecond electric pulses
| hal.structure.identifier | Institut für Hochleistungsimpuls - und Mikrowellentechnik [Karlsruhe] | |
| dc.contributor.author | SILVE, Aude | |
| hal.structure.identifier | Vectorologie et thérapeutiques anti-cancéreuses [Villejuif] [UMR 8203] | |
| dc.contributor.author | LERAY, Isabelle | |
| hal.structure.identifier | Modélisation Mathématique pour l'Oncologie [MONC] | |
| hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
| dc.contributor.author | POIGNARD, Clair | |
| hal.structure.identifier | Vectorologie et thérapeutiques anti-cancéreuses [Villejuif] [UMR 8203] | |
| dc.contributor.author | MIR, Lluis M. | |
| dc.date.accessioned | 2024-04-04T03:15:38Z | |
| dc.date.available | 2024-04-04T03:15:38Z | |
| dc.date.issued | 2016-02 | |
| dc.identifier.issn | 2045-2322 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/194155 | |
| dc.description.abstractEn | The impact of external medium conductivity on the efficiency of the reversible permeabilisation caused by pulsed electric fields was investigated. Pulses of 12 ns, 102 ns or 100 μs were investigated. Whenever permeabilisation could be detected after the delivery of one single pulse, media of lower conductivity induced more efficient reversible permeabilisation and thus independently of the medium composition. Effect of medium conductivity can however be hidden by some saturation effects, for example when pulses are cumulated (use of trains of 8 pulses) or when the detection method is not sensitive enough. This explains the contradicting results that can be found in the literature. The new data are complementary to those of one of our previous study in which an opposite effect of the conductivity was highlighted. It stresses that the conductivity of the medium influences the reversible permeabilization by several ways. Moreover, these results clearly indicate that electropermeabilisation does not linearly depend on the energy delivered to the cells. | |
| dc.language.iso | en | |
| dc.publisher | Nature Publishing Group | |
| dc.title.en | Impact of external medium conductivity on cell membrane electropermeabilization by microsecond and nanosecond electric pulses | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1038/srep19957 | |
| dc.subject.hal | Mathématiques [math]/Equations aux dérivées partielles [math.AP] | |
| bordeaux.journal | Scientific Reports | |
| bordeaux.volume | 6 | |
| bordeaux.hal.laboratories | Institut de Mathématiques de Bordeaux (IMB) - UMR 5251 | * |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | CNRS | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-01266274 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-01266274v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2016-02&rft.volume=6&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=SILVE,%20Aude&LERAY,%20Isabelle&POIGNARD,%20Clair&MIR,%20Lluis%20M.&rft.genre=article |
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