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Reduced Sodium Current in the Lateral Ventricular Wall Induces Inferolateral J-Waves

hal.structure.identifierAcademic Medical Center - Academisch Medisch Centrum [Amsterdam] [AMC]
dc.contributor.authorMEIJBORG, Veronique
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
hal.structure.identifierIHU-LIRYC
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorPOTSE, Mark
hal.structure.identifierAcademic Medical Center - Academisch Medisch Centrum [Amsterdam] [AMC]
dc.contributor.authorCONRATH, Chantal
hal.structure.identifierIHU-LIRYC
hal.structure.identifierAcademic Medical Center - Academisch Medisch Centrum [Amsterdam] [AMC]
dc.contributor.authorBELTERMAN, Charly
hal.structure.identifierAcademic Medical Center - Academisch Medisch Centrum [Amsterdam] [AMC]
dc.contributor.authorDE BAKKER, Jacques
hal.structure.identifierIHU-LIRYC
hal.structure.identifierAcademic Medical Center - Academisch Medisch Centrum [Amsterdam] [AMC]
dc.contributor.authorCORONEL, Ruben
dc.date.accessioned2024-04-04T03:13:23Z
dc.date.available2024-04-04T03:13:23Z
dc.date.issued2016-08-26
dc.identifier.issn1664-042X
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/193946
dc.description.abstractEnBackground: J-waves in inferolateral leads are associated with a higher risk for idiopathic ventricular fibrillation. We aimed to test potential mechanisms (depolarization or repolarization dependent) responsible for inferolateral J-waves. We hypothesized that inferolateral J-waves can be caused by regional delayed activation of myocardium that is activated late during normal conditions.Methods: Computer simulations were performed to evaluate how J-point elevation is influenced by reducing sodium current conductivity (GNa), increasing transient outward current conductivity (Gto), or cellular uncoupling in three predefined ventricular regions (lateral, anterior, or septal). Two pig hearts were Langendorff-perfused with selective perfusion with a sodium channel blocker of lateral or anterior/septal regions. Volume-conducted pseudo-electrocardiograms (ECG) were recorded to detect the presence of J-waves. Epicardial unipolar electrograms were simultaneously recorded to obtain activation times (AT).Results: Simulation data showed that conduction slowing, caused by reduced sodium current, in lateral, but not in other regions induced inferolateral J-waves. An increase in transient outward potassium current or cellular uncoupling in the lateral zone elicited slight J-point elevations which did not meet J-wave criteria. Additional conduction slowing in the entire heart attenuated J-waves and J-point elevations on the ECG, because of masking by the QRS. Experimental data confirmed that conduction slowing attributed to sodium channel blockade in the left lateral but not in the anterior/septal ventricular region induced inferolateral J-waves. J-waves coincided with the delayed activation.Conclusion: Reduced sodium current in the left lateral ventricular myocardium can cause inferolateral J-waves on the ECG.
dc.language.isoen
dc.publisherFrontiers
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enJ-wave
dc.subject.enearly repolarization
dc.subject.endepolarization
dc.subject.enconduction
dc.subject.encellular uncoupling
dc.subject.ensodium current
dc.title.enReduced Sodium Current in the Lateral Ventricular Wall Induces Inferolateral J-Waves
dc.typeArticle de revue
dc.identifier.doi10.3389/fphys.2016.00365
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
bordeaux.journalFrontiers in Physiology
bordeaux.volume7
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue365
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01386905
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01386905v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Physiology&rft.date=2016-08-26&rft.volume=7&rft.issue=365&rft.eissn=1664-042X&rft.issn=1664-042X&rft.au=MEIJBORG,%20Veronique&POTSE,%20Mark&CONRATH,%20Chantal&BELTERMAN,%20Charly&DE%20BAKKER,%20Jacques&rft.genre=article


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