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Computational Trials: Unraveling Motility Phenotypes, Progression Patterns, and Treatment Options for Glioblastoma Multiforme
hal.structure.identifier | University of Alabama at Birmingham [ Birmingham] [UAB] | |
dc.contributor.author | RAMAN, Fabio | |
hal.structure.identifier | Department of neurology [Birmingham, Alabama] | |
hal.structure.identifier | Department of Mathematics [Birmingham, Alabama] | |
dc.contributor.author | SCRIBNER, Elizabeth | |
hal.structure.identifier | Modélisation Mathématique pour l'Oncologie [MONC] | |
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
dc.contributor.author | SAUT, Olivier | |
hal.structure.identifier | Faculdade de Ciências [Lisboa] | |
dc.contributor.author | WENGER, Cornelia | |
hal.structure.identifier | Modélisation Mathématique pour l'Oncologie [MONC] | |
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
dc.contributor.author | COLIN, Thierry | |
hal.structure.identifier | Department of neurology [Birmingham, Alabama] | |
hal.structure.identifier | Department of Mathematics [Birmingham, Alabama] | |
dc.contributor.author | FATHALLAH-SHAYKH, Hassan | |
dc.date.accessioned | 2024-04-04T03:13:05Z | |
dc.date.available | 2024-04-04T03:13:05Z | |
dc.date.issued | 2016-01-12 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/193926 | |
dc.description.abstractEn | Glioblastoma multiforme is a malignant brain tumor with poor prognosis and high morbidity due to its invasiveness. Hypoxia-driven motility and concentration-driven motility are two mechanisms of glioblastoma multiforme invasion in the brain. The use of anti-angiogenic drugs has uncovered new progression patterns of glioblastoma multiforme associated with significant differences in overall survival. Here, we apply a mathematical model of glioblas- toma multiforme growth and invasion in humans and design computational trials using agents that target angiogenesis, tumor replication rates, or motility. The findings link highly- dispersive, moderately-dispersive, and hypoxia-driven tumors to the patterns observed in glioblastoma multiforme treated by anti-angiogenesis, consisting of progression by Expand- ing FLAIR, Expanding FLAIR + Necrosis, and Expanding Necrosis, respectively. Further- more, replication rate-reducing strategies (e.g. Tumor Treating Fields) appear to be effective in highly-dispersive and moderately-dispersive tumors but not in hypoxia-driven tumors. The latter may respond to motility-reducing agents. In a population computational trial, with all three phenotypes, a correlation was observed between the efficacy of the rate- reducing agent and the prolongation of overall survival times. This research highlights the potential applications of computational trials and supports new hypotheses on glioblastoma multiforme phenotypes and treatment options. | |
dc.language.iso | en | |
dc.publisher | Public Library of Science | |
dc.title.en | Computational Trials: Unraveling Motility Phenotypes, Progression Patterns, and Treatment Options for Glioblastoma Multiforme | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1371/journal.pone.0146617 | |
dc.subject.hal | Informatique [cs]/Modélisation et simulation | |
dc.subject.hal | Sciences du Vivant [q-bio]/Cancer | |
dc.subject.hal | Mathématiques [math]/Equations aux dérivées partielles [math.AP] | |
bordeaux.journal | PLoS ONE | |
bordeaux.volume | 11 | |
bordeaux.hal.laboratories | Institut de Mathématiques de Bordeaux (IMB) - UMR 5251 | * |
bordeaux.issue | 1 | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | CNRS | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-01396271 | |
hal.version | 1 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-01396271v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS%20ONE&rft.date=2016-01-12&rft.volume=11&rft.issue=1&rft.eissn=1932-6203&rft.issn=1932-6203&rft.au=RAMAN,%20Fabio&SCRIBNER,%20Elizabeth&SAUT,%20Olivier&WENGER,%20Cornelia&COLIN,%20Thierry&rft.genre=article |
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