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Microscopic Modelling of the Non-Linear Gap Junction Channels

hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierIHU-LIRYC
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorDAVIDOVIĆ, Anđela
hal.structure.identifierIHU-LIRYC
hal.structure.identifierUniversité de Bordeaux [UB]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorCOUDIÈRE, Yves
hal.structure.identifierIHU-LIRYC
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorDESPLANTEZ, Thomas
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation Mathématique pour l'Oncologie [MONC]
dc.contributor.authorPOIGNARD, Clair
dc.date.accessioned2024-04-04T03:12:05Z
dc.date.available2024-04-04T03:12:05Z
dc.date.conference2015-09-06
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/193833
dc.description.abstractEnThe usual way to model the propagation of the action potential through the cardiac tissue is to assume passive diffusive intracellular and extracellular domains, and ion channel dynamics on the cells' membrane. Gap junctions (GJ) are localised clusters of gap junction channels (GJCs) that connects electrically adjacent cells. The importance of GJCs and their modifications in the signal propagation has been demonstrated in the experimental studies (e.g. Beauchamp et al 2012). But, in the current mathematical models the behaviour of the GJCs is either neglected or assumed to be passive, i.e the conductance of GJCs is taken as a steady constant. On the other hand, the experimental results, obtained by the dual-voltage clamp technique, show that GJCs are time and voltage dependent. Here we focus on describing ventricular GJCs made of connexin Cx43 and Cx45. We use the Hodgkin-Huxley formalism to describe GJC conductance via one gating variable. We incorporate the non-linear GJC voltage dependence into the microscopic model of the tissue as a new boundary condition on specific parts of the cells' membranes .
dc.description.sponsorshipModèles numériques haute résolution de l'électrophysiologie cardiaque - ANR-13-MONU-0004
dc.language.isoen
dc.subject.enGap junction
dc.subject.enNon linear model
dc.subject.enMicroscopic modelling
dc.title.enMicroscopic Modelling of the Non-Linear Gap Junction Channels
dc.typeCommunication dans un congrès
dc.subject.halMathématiques [math]
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.conference.title2015 Computing in Cardiology Conference (CinC)
bordeaux.countryFR
bordeaux.conference.cityNice
bordeaux.peerReviewedoui
hal.identifierhal-01418702
hal.version1
hal.invitednon
hal.proceedingsoui
hal.conference.end2015-09-09
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01418702v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=DAVIDOVI%C4%86,%20An%C4%91ela&COUDI%C3%88RE,%20Yves&DESPLANTEZ,%20Thomas&POIGNARD,%20Clair&rft.genre=unknown


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