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The relation between local repolarization and T-wave morphology in heart failure patients

hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
dc.contributor.authorMAFFESSANTI, Francesco
hal.structure.identifierMaastricht University [Maastricht]
dc.contributor.authorWANTEN, Joris
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierIHU-LIRYC
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
dc.contributor.authorPOTSE, Mark
hal.structure.identifierCardiocentro Ticino [Lugano]
dc.contributor.authorREGOLI, Francois
hal.structure.identifierCardiocentro Ticino [Lugano]
dc.contributor.authorCAPUTO, Maria
hal.structure.identifierCardiocentro Ticino [Lugano]
dc.contributor.authorCONTE, Giulio
hal.structure.identifierCardiocentro Ticino [Lugano]
dc.contributor.authorSÜRDER, Daniel
hal.structure.identifierOtto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] [OVGU]
hal.structure.identifierCardiocentro Ticino [Lugano]
dc.contributor.authorILLNER, Annekatrin
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
dc.contributor.authorKRAUSE, Rolf
hal.structure.identifierCardiocentro Ticino [Lugano]
dc.contributor.authorMOCCETTI, Tiziano
hal.structure.identifierCardiocentro Ticino [Lugano]
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
dc.contributor.authorAURICCHIO, Angelo
hal.structure.identifierMaastricht University [Maastricht]
dc.contributor.authorPRINZEN, Frits
dc.date.accessioned2024-04-04T03:09:34Z
dc.date.available2024-04-04T03:09:34Z
dc.date.created2016-12-06
dc.date.issued2017-02-22
dc.identifier.issn0167-5273
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/193616
dc.description.abstractEnBackground: Both duration and morphology of the T-wave are regarded important parameters describing repo-larization of the ventricles. Conventionally, T-wave concordance is explained by an inverse relation between the time of depolarization (TD) and repolarization (TR). Little is known about T-wave morphology and TD-TR relations in patients with heart failure. Methods: Electro-anatomic maps were obtained in the left (LV) and right ventricle (RV) and in the coronary sinus (CS) in patients with heart failure with narrow (nQRS, n = 8) and wide QRS complex with (LBBB, n = 15) and without left bundle branch block (non-LBBB, n = 7). TD and TR were determined from the thus acquired electro-grams. Results: In nQRS and non-LBBB patients, TD-TR relations had a slope between 0 and +1, indicating that repolar-ization followed the sequence of depolarization. In LBBB patients, repolarization occurred significantly earlier in the RV than in the LV, fitting with the idea that the discordant T-waves in LBBB are secondary to the abnormal depolarization sequence. However, the slopes of the TD-TR relations in the LV and CS were not significantly different from zero, indicating no major spatial gradient in LV repolarization, despite a considerable gradient in de-polarization. Remarkable was also the large (~100 ms) transseptal gradient in repolarization. Values of the slopes of the TD-TR relation overlapped between the three patient groups, despite a difference in T-wave morphology between LBBB (all discordant) and nQRS patients (all flat/biphasic). Conclusions: Discordant T-waves in LBBB patients are explained by interventricular dispersion in repolarization. T-wave morphology is determined by more factors than the TD-TR relation alone.
dc.language.isoen
dc.publisherElsevier
dc.subject.enHeart failure
dc.subject.enLeft bundle branch block
dc.subject.enRepolarization
dc.subject.enT-wave
dc.subject.enElectro-anatomic mapping
dc.subject.meshC14.280.434
dc.subject.meshCardiac Electrophysiology
dc.title.enThe relation between local repolarization and T-wave morphology in heart failure patients
dc.typeArticle de revue
dc.identifier.doi10.1016/j.ijcard.2017.02.056
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
bordeaux.journalInternational Journal of Cardiology
bordeaux.page270 - 276
bordeaux.volume241
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01567816
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01567816v1
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