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Rapid dynamic R1/R2*/temperature assessment: a method with potential for monitoring drug delivery

hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorLORENZATO, Cyril
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorOERLEMANS, Chris
hal.structure.identifierMedisysResearch Lab [Medisys]
dc.contributor.authorCERNICANU, Alexandru
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorRIES, Mario
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorDENIS DE SENNEVILLE, Baudouin
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorMOONEN, Chrit
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorBOS, Clemens
dc.date.accessioned2024-04-04T03:09:13Z
dc.date.available2024-04-04T03:09:13Z
dc.date.issued2014
dc.identifier.issn0952-3480
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/193588
dc.description.abstractEnLocal drug delivery by hyperthermia-induced drug release from thermosensitive liposomes (TSLs) may reduce the systemic toxicity of chemotherapy, whilst maintaining or increasing its efficacy. Relaxivity contrast agents can be co-encapsulated with the drug to allow the visualization of the presence of liposomes, by means of R 2 *, as well as the co-release of the contrast agent and the drug, by means of R 1, on heating. Here, the mathematical method used to extract both R 2 * and R 1 from a fast dynamic multi-echo spoiled gradient echo (ME-SPGR) is presented and analyzed. Finally, this method is used to monitor such release events. R 2 * was obtained from a fit to the ME-SPGR data. Absolute R 1 was calculated from the signal magnitude changes corrected for the apparent proton density changes and a baseline Look–Locker R 1 map. The method was used to monitor nearly homogeneous water bath heating and local focused ultrasound heating of muscle tissue, and to visualize the release of a gadolinium chelate from TSLs in vitro. R 2 *, R 1 and temperature maps were measured with a 5-s temporal resolution. Both R 2 *and R 1 measured were found to change with temperature. The dynamic R 1 measurements after heating agreed with the Look–Locker R 1 values if changes in equilibrium magnetization with temperature were considered. Release of gadolinium from TSLs was detected by an R 1 increase near the phase transition temperature, as well as a shallow R 2 * increase. Simultaneous temperature, R 2 * and R 1 mapping is feasible in real time and has the potential for use in image-guided drug delivery studies.
dc.language.isoen
dc.publisherWiley
dc.subject.enmulti-echo spoiled gradient echo
dc.subject.enhigh-intensity focused ultrasound
dc.subject.enfocused ultrasound
dc.subject.enR2*
dc.subject.enrelaxometry
dc.subject.enR1
dc.subject.enMRI
dc.subject.enapparent proton density
dc.subject.endrug delivery system
dc.subject.enthermosensitive liposome
dc.title.enRapid dynamic R1/R2*/temperature assessment: a method with potential for monitoring drug delivery
dc.typeArticle de revue
dc.identifier.doi10.1002/nbm.3182
dc.subject.halSciences de l'ingénieur [physics]/Traitement du signal et de l'image
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale/Imagerie
dc.subject.halSciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacologie
bordeaux.journalNMR in Biomedicine
bordeaux.page1267-1274
bordeaux.volume27
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue11
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01578215
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01578215v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=NMR%20in%20Biomedicine&rft.date=2014&rft.volume=27&rft.issue=11&rft.spage=1267-1274&rft.epage=1267-1274&rft.eissn=0952-3480&rft.issn=0952-3480&rft.au=LORENZATO,%20Cyril&OERLEMANS,%20Chris&CERNICANU,%20Alexandru&RIES,%20Mario&DENIS%20DE%20SENNEVILLE,%20Baudouin&rft.genre=article


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