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On-line MR imaging for dose validation of abdominal radiotherapy

hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorGLITZNER, Markus
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorCRIJNS, Sjoerd
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorDENIS DE SENNEVILLE, Baudouin
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorKONTAXIS, Charis
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorPRINS, Fieke
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorLAGENDIJK, Jan
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorRAAYMAKERS, Bas
dc.date.accessioned2024-04-04T03:09:04Z
dc.date.available2024-04-04T03:09:04Z
dc.date.issued2015
dc.identifier.issn0031-9155
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/193580
dc.description.abstractEnFor quality assurance and adaptive radiotherapy, validation of the actual delivered dose is crucial.Intrafractional anatomy changes cannot be captured satisfactorily during treatment with hitherto available imaging modalitites. Consequently, dosecalculations are based on the assumption of static anatomy throughout the treatment. However, intra- and interfraction anatomy is dynamic and changes can be significant. In particular, hypofractionated and escalated radiotherapy thus demand for reliable dose reconstruction based on periodic imaging.In this paper, we investigate the use of an MR -linac as a dose tracking modality for the validation of treatments in abdominal targets where both respiratory and long-term peristaltic and drift motion occurs.The on-line MR imaging capabilities of the modality provides the means to perform respiratory gating of both delivery and acquisition yielding a model-free respiratory motion management under free breathing conditions.In parallel to the treatment, the volumetric patient anatomy was captured and used to calculate the applied dose. Subsequently, the individual doses were warped back to the planing grid to obtain the actual dose accumulated over the entire treatment duration. Eventually, the planned dose was validated by comparison with the accumulated dose.Representatively for a site subject to breathing modulation, two kidney cases (25Gy target dose) demonstrated the working principle on volunteer data and simulated delivery. The proposed workflow successfully showed its ability to track local dosimetric changes. Integration of the on-line anatomy information could reveal local dose variations −2.3 to 1.5Gy in the target volume of a volunteer dataset. In the adjacent organs at risk, high local dose errors ranging from −2.5 to 1.9Gy could be traced back.
dc.language.isoen
dc.publisherIOP Publishing
dc.title.enOn-line MR imaging for dose validation of abdominal radiotherapy
dc.typeArticle de revue
dc.subject.halSciences de l'ingénieur [physics]/Traitement du signal et de l'image
bordeaux.journalPhysics in Medicine and Biology
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01211405
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01211405v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Physics%20in%20Medicine%20and%20Biology&rft.date=2015&rft.eissn=0031-9155&rft.issn=0031-9155&rft.au=GLITZNER,%20Markus&CRIJNS,%20Sjoerd&DENIS%20DE%20SENNEVILLE,%20Baudouin&KONTAXIS,%20Charis&PRINS,%20Fieke&rft.genre=article


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