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Anatomically-induced Fibrillation in a 3D model of the Human Atria

hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierIHU-LIRYC
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorPOTSE, Mark
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
hal.structure.identifierInstitute of Computational Science [ICS]
dc.contributor.authorGHARAVIRI, Ali
hal.structure.identifierFaculty of Informatics [Lugano]
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
hal.structure.identifierInstitute of Computational Science [ICS]
dc.contributor.authorPEZZUTO, Simone
hal.structure.identifierCardiocentro Ticino [Lugano]
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
dc.contributor.authorAURICCHIO, Angelo
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
hal.structure.identifierInstitute of Computational Science [ICS]
dc.contributor.authorKRAUSE, Rolf
hal.structure.identifierInstitute of Computational Science [ICS]
hal.structure.identifierDepartment of Physiology [Maastricht]
dc.contributor.authorVERHEULE, Sander
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
hal.structure.identifierDepartment of Physiology [Maastricht]
dc.contributor.authorSCHOTTEN, Ulrich
dc.date.accessioned2024-04-04T03:04:40Z
dc.date.available2024-04-04T03:04:40Z
dc.date.conference2018-09-24
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/193174
dc.description.abstractEnAtrial fibrillation (AF) requires both a trigger and a sub-strate that can maintain a complex reentrant activity. In patients and in experimental models this substrate is provided by both electrical and structural remodeling. Since these processes overlap in time it is impossible to assess their individual contributions to AF maintenance experimentally. Therefore we studied the effect of electrical re-modeling alone on AF initiation in a realistic numerical model of the human atria. We attempted to initiate AF by rapid pacing in 10 different locations, both with and without electrical remodeling. The protocols were repeated twice, with small variations in calcium conductivity, so that in total 30 simulations with and 30 simulations without remodeling were performed. In models with electrical remodeling, functional conduction block at structural in-homogeneities induced AF in 27 % of the simulations. In models without electrical remodeling, AF could not be induced. We conclude that in the complex anatomy of the atria electrical remodeling alone increases the probability of AF substantially. This finding supports a mechanism whereby electrical remodeling, which occurs relatively fast, accelerates the slower but irreversible structural remodeling process.
dc.language.isoen
dc.title.enAnatomically-induced Fibrillation in a 3D model of the Human Atria
dc.typeCommunication dans un congrès
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
dc.subject.halInformatique [cs]/Modélisation et simulation
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.conference.titleComputing in Cardiology
bordeaux.countryNL
bordeaux.conference.cityMaastricht
bordeaux.peerReviewedoui
hal.identifierhal-01910674
hal.version1
hal.invitednon
hal.proceedingsoui
hal.conference.end2018-09-26
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01910674v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=POTSE,%20Mark&GHARAVIRI,%20Ali&PEZZUTO,%20Simone&AURICCHIO,%20Angelo&KRAUSE,%20Rolf&rft.genre=unknown


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