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Controlling IL-7 injections in HIV-infected patients

hal.structure.identifierVaccine Research Institute [Créteil, France] [VRI]
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
dc.contributor.authorPASIN, Chloé
hal.structure.identifierQuality control and dynamic reliability [CQFD]
dc.contributor.authorDUFOUR, François
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierVaccine Research Institute [Créteil, France] [VRI]
dc.contributor.authorVILLAIN, Laura
hal.structure.identifierQuality control and dynamic reliability [CQFD]
dc.contributor.authorZHANG, Huilong
hal.structure.identifierVaccine Research Institute [Créteil, France] [VRI]
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
dc.contributor.authorTHIÉBAUT, Rodolphe
dc.date.accessioned2024-04-04T03:04:02Z
dc.date.available2024-04-04T03:04:02Z
dc.date.issued2018-08-02
dc.identifier.issn0092-8240
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/193115
dc.description.abstractEnImmune interventions consisting in repeated injections are broadly used as they are thought to improve the quantity and the quality of the immune response. However, they also raise several questions that remain unan-swered, in particular the number of injections to make or the delay to respect between different injections to achieve this goal. Practical and financial considerations add constraints to these questions, especially in the framework of human studies. We specifically focus here on the use of interleukin-7 (IL-7) injections in HIV-infected patients under antiretroviral treatment, but still unable to restore normal levels of CD4 + T lymphocytes. Clinical trials have already shown that repeated cycles of injections of IL-7 could help maintaining CD4 + T lymphocytes levels over the limit of 500 cells/µL, by affecting proliferation and survival of CD4 + T cells. We then aim at answering the question : how to maintain a patients level of CD4 + T lymphocytes by using a minimum number of injections (i.e., optimizing the strategy of injections) ? Based on mechanistic models that were previously developed for the dynamics of CD4+ T lymphocytes in this context, we model the process by a piecewise deter-ministic Markov model. We then address the question by using some recently 2 Chloé Pasin et al. established theory on impulse control problem in order to develop a numerical tool determining the optimal strategy. Results are obtained on a reduced model, as a proof of concept: the method allows to define an optimal strategy for a given patient. This method could be applied to optimize injections schedules in clinical trials.
dc.description.sponsorshipInitiative for the creation of a Vaccine Research Institute - ANR-10-LABX-0077
dc.language.isoen
dc.publisherSpringer Verlag
dc.subject.enDynamic programming
dc.subject.enImmune therapy
dc.subject.enOptimal control
dc.title.enControlling IL-7 injections in HIV-infected patients
dc.typeArticle de revue
dc.identifier.doi10.1007/s11538-018-0465-8
dc.subject.halMathématiques [math]/Optimisation et contrôle [math.OC]
dc.subject.halSciences du Vivant [q-bio]/Immunologie
bordeaux.journalBulletin of Mathematical Biology
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-03063888
hal.version2
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03063888v2
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Bulletin%20of%20Mathematical%20Biology&rft.date=2018-08-02&rft.eissn=0092-8240&rft.issn=0092-8240&rft.au=PASIN,%20Chlo%C3%A9&DUFOUR,%20Fran%C3%A7ois&VILLAIN,%20Laura&ZHANG,%20Huilong&THI%C3%89BAUT,%20Rodolphe&rft.genre=article


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