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A mathematical model to investigate the key drivers of the biogeography of the colon microbiota.

hal.structure.identifierMathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] [MaIAGE]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorLABARTHE, Simon
hal.structure.identifierInstitut Camille Jordan [ICJ]
dc.contributor.authorPOLIZZI, Bastien
hal.structure.identifierInstitut Denis Poisson [IDP]
dc.contributor.authorPHAN, Thuy
hal.structure.identifierCOmplex Flows For Energy and Environment [COFFEE]
hal.structure.identifierLaboratoire Jean Alexandre Dieudonné [LJAD]
dc.contributor.authorGOUDON, Thierry
hal.structure.identifierInstitut Denis Poisson [IDP]
dc.contributor.authorRIBOT, Magali
hal.structure.identifierMathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] [MaIAGE]
dc.contributor.authorLAROCHE, Béatrice
dc.date.accessioned2024-04-04T03:03:32Z
dc.date.available2024-04-04T03:03:32Z
dc.date.issued2019
dc.identifier.issn0022-5193
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/193081
dc.description.abstractEnThe gut microbiota, mainly located in the colon, is engaged in a complex dialogue with the large intestinal epithelium through which important regulatory processes for the health and well-being of the host take place. Imbalances of the microbial populations, called dysbiosis, are related to several pathological status, emphasizing the importance of understanding the gut bacterial ecology. Among the ecological drivers of the microbiota, the spatial structure of the colon is of special interest: spatio-temporal mechanisms can lead to the constitution of spatial interactions among the bacterial populations and of en-vironemental niches that impact the overall colonization of the colon. In the present study, we introduce a mathematical model of the colon microbiota in its fluid environment, based on the explicit coupling of a population dynamics model of microbial populations involved in fibre degradation with a fluid dynamics model of the luminal content. This modelling framework is used to study the main drivers of the spatial structure of the microbiota, specially focusing on the dietary fibres, the epithelial motility, the microbial active swimming and viscosity gradients in the digestive track. We found 1) that the viscosity gradients allow the creation of favourable niches in the vicinity of the mucus layer; 2) that very low microbial active swimming in the radial direction is enough to promote bacterial growth, which shed a new light on microbial motility in the colon and 3) that dietary fibres are the main driver of the spatial structure of the microbiota in the distal bowel whereas epithelial motility is preponderant for the colonization of the proximal colon; in the transverse colon, fibre levels and chemotaxis have the strongest impact on the distribution of the microbial communities.
dc.language.isoen
dc.publisherElsevier
dc.subject.enpopulation dynamics
dc.subject.enmicrobial ecology
dc.subject.enfluid mechanics
dc.subject.engut microbiota
dc.subject.enmathematical model
dc.subject.enPDE
dc.title.enA mathematical model to investigate the key drivers of the biogeography of the colon microbiota.
dc.typeArticle de revue
dc.identifier.doi10.1016/j.jtbi.2018.12.009
dc.subject.halMathématiques [math]/Analyse numérique [math.NA]
dc.subject.halMathématiques [math]/Equations aux dérivées partielles [math.AP]
dc.subject.halInformatique [cs]/Modélisation et simulation
dc.subject.halSciences du Vivant [q-bio]/Bio-Informatique, Biologie Systémique [q-bio.QM]
dc.description.sponsorshipEuropeAgreenSkills+
bordeaux.journalJournal of Theoretical Biology
bordeaux.page552-581
bordeaux.volume462
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue7
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01761191
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01761191v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Theoretical%20Biology&rft.date=2019&rft.volume=462&rft.issue=7&rft.spage=552-581&rft.epage=552-581&rft.eissn=0022-5193&rft.issn=0022-5193&rft.au=LABARTHE,%20Simon&POLIZZI,%20Bastien&PHAN,%20Thuy&GOUDON,%20Thierry&RIBOT,%20Magali&rft.genre=article


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