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Distinct Characteristics Of Human Ventricular Fibrillation In Its Initial Phase

hal.structure.identifierIHU-LIRYC
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierDépartement de cardiologie
dc.contributor.authorHAÏSSAGUERRE, Michel
hal.structure.identifierIHU-LIRYC
dc.contributor.authorDUCHATEAU, Josselin
hal.structure.identifierDépartement de cardiologie
dc.contributor.authorCHENITI, Ghassen
hal.structure.identifierIHU-LIRYC
dc.contributor.authorPUYO, Stéphane
hal.structure.identifierIHU-LIRYC
hal.structure.identifierDépartement de cardiologie
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorDENIS, Arnaud
hal.structure.identifierCHU Bordeaux
hal.structure.identifierIHU-LIRYC
dc.contributor.authorCOCHET, Hubert
hal.structure.identifierIHU-LIRYC
dc.contributor.authorMEO, Marianna
hal.structure.identifierCHU Bordeaux
hal.structure.identifierIHU-LIRYC
dc.contributor.authorKITAMURA, Takeshi
hal.structure.identifierIHU-LIRYC
hal.structure.identifierCHU Bordeaux
dc.contributor.authorTAKIGAWA, Masateru
hal.structure.identifierDépartement de cardiologie
dc.contributor.authorFRONTERA, Antonio
hal.structure.identifierUniversity Hospital of Ioannina
dc.contributor.authorVLACHOS, Konstantinos George
hal.structure.identifierIHU-LIRYC
dc.contributor.authorMASSOULLIÉ, Grégoire
hal.structure.identifierHôpital de l'Ile
dc.contributor.authorLAM, Anna
hal.structure.identifierIHU-LIRYC
dc.contributor.authorBOURIER, Felix
hal.structure.identifierIHU-LIRYC
hal.structure.identifierDépartement de cardiologie
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorPAMBRUN, Thomas
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorWELTE, Nicolas
hal.structure.identifierIHU-LIRYC
hal.structure.identifierDépartement de cardiologie
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorDERVAL, Nicolas
hal.structure.identifierHôpital Haut-Lévêque [CHU Bordeaux]
dc.contributor.authorAMRAOUI, Sana
hal.structure.identifierIHU-LIRYC
dc.contributor.authorKLOTZ, Nicolas
hal.structure.identifierIHU-LIRYC
hal.structure.identifierCHU Bordeaux
dc.contributor.authorSACHER, Fréderic
hal.structure.identifierHôpital Haut-Lévêque [CHU Bordeaux]
dc.contributor.authorBORDACHAR, Pierre
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorPLOUX, Sylvain
hal.structure.identifierCHU Bordeaux
dc.contributor.authorRITTER, Philippe
hal.structure.identifierIHU-LIRYC
dc.contributor.authorJAÏS, Pierre
hal.structure.identifierIHU-LIRYC
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorVIGMOND, Edward J.
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorPOTSE, Mark
hal.structure.identifierIHU-LIRYC
dc.contributor.authorWALTON, Richard D.
hal.structure.identifierIHU-LIRYC
dc.contributor.authorDUBOIS, Rémi
hal.structure.identifierIHU-LIRYC
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorBERNUS, Olivier
hal.structure.identifierDépartement de cardiologie
hal.structure.identifierIHU-LIRYC
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorHOCINI, Meleze
dc.date.accessioned2024-04-04T03:03:08Z
dc.date.available2024-04-04T03:03:08Z
dc.date.issued2018-05
dc.date.conference2018-05-09
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/193046
dc.description.abstractEnBackground: Ventricular fibrillation (VF) progresses rapidly from an initial organized stage to chaotic fibrillation. The characteristics of initial drivers, that may be critical for therapeutic interventions, have not been investigated.Objective: To characterize the initial drivers of Human VFMethods: We evaluated 51 patients (44±10 years) who survived VF associated with ischemic heart disease in 15, cardiomyopathy in 14 and Brugada syndrome in 22. VF was mapped by intracardiac and body-surface recordings to analyze spatial organization, cycle lengths (CL), and drivers at the origin of wavefronts. We performed endocardial and epicardial mapping during sinus rhythm. The abnormal substrate was identified as areas of low voltage (≤1mV) and fragmented signals (≥70ms).Results: We mapped 69 episodes of spontaneous (n=12) or induced (n=57) VF for 17±10 s. The VF CL decreased from 208±28 to 172±25 ms (p<0.001) with the fastest acceleration consistently occurring in the initial 5 s. Initial organized VF, lasting 4.3 ± 1s, showed recurring wavefront sequences arising from distinct driver areas of focal or reentrant activity. These drivers were specifically associated with the abnormal ventricular substrate: in Brugada syndrome, they originated from individual locations in the right ventricle whereas in ischemic heart disease or cardiomyopathy, they originated dominantly from scar borderline in the left ventricle. In contrast, during the disorganized VF phase, the drivers were disseminated in both ventricles producing widespread unstable reentries without specific link with underlying ventricular substrate. In 32 patients, the driver areas were ablated using radiofrequency energy resulting in arrhythmia-free outcome in 27 patients at 20±19 months follow- up.Conclusion: The early phase in which human VF appears electrocardiographically well-organized, is unique as it is associated with a limited number of drivers distinctly related to underlying abnormal substrate. These primary drivers will then rapidly accelerate and disseminate to establish disorganized fibrillation.
dc.language.isoen
dc.publisherHeart Rhythm Society
dc.title.enDistinct Characteristics Of Human Ventricular Fibrillation In Its Initial Phase
dc.typeCommunication dans un congrès
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.conference.titleHeart Rhythm Meeting - 39th Annual Scientific Sessions
bordeaux.countryUS
bordeaux.conference.cityBoston
bordeaux.peerReviewedoui
hal.identifierhal-01954669
hal.version1
hal.invitednon
hal.proceedingsnon
hal.conference.end2018-05-12
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01954669v1
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.date=2018-05&amp;rft.au=HA%C3%8FSSAGUERRE,%20Michel&amp;DUCHATEAU,%20Josselin&amp;CHENITI,%20Ghassen&amp;PUYO,%20St%C3%A9phane&amp;DENIS,%20Arnaud&amp;rft.genre=unknown


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