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hal.structure.identifierIHU-LIRYC
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierDépartement de cardiologie
dc.contributor.authorHAÏSSAGUERRE, Michel
hal.structure.identifierDépartement de cardiologie
hal.structure.identifierIHU-LIRYC
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorHOCINI, Meleze
hal.structure.identifierIHU-LIRYC
dc.contributor.authorPUYO, Stéphane
hal.structure.identifierDépartement de cardiologie
dc.contributor.authorCHENITI, Ghassen
hal.structure.identifierIHU-LIRYC
dc.contributor.authorDUCHATEAU, Josselin
hal.structure.identifierIHU-LIRYC
hal.structure.identifierDépartement de cardiologie
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorDENIS, Arnaud
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorCOCHET, Hubert
hal.structure.identifierIHU-LIRYC
dc.contributor.authorMEO, Marianna
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorKITAMURA, Takeshi
hal.structure.identifierIHU-LIRYC
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorTAKIGAWA, Masateru
hal.structure.identifierDépartement de cardiologie
dc.contributor.authorFRONTERA, Antonio
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorVLACHOS, Konstantinos George
hal.structure.identifierIHU-LIRYC
dc.contributor.authorMASSOULLIÉ, Grégoire
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorLAM, Anna
hal.structure.identifierIHU-LIRYC
dc.contributor.authorBOURIER, Felix
hal.structure.identifierIHU-LIRYC
hal.structure.identifierDépartement de cardiologie
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorPAMBRUN, Thomas
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorWELTE, Nicolas
hal.structure.identifierIHU-LIRYC
hal.structure.identifierDépartement de cardiologie
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorDERVAL, Nicolas
hal.structure.identifierHôpital Haut-Lévêque [CHU Bordeaux]
dc.contributor.authorAMRAOUI, Sana
hal.structure.identifierIHU-LIRYC
dc.contributor.authorKLOTZ, Nicolas
hal.structure.identifierIHU-LIRYC
dc.contributor.authorSACHER, Fréderic
hal.structure.identifierHôpital Haut-Lévêque [CHU Bordeaux]
dc.contributor.authorBORDACHAR, Pierre
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorPLOUX, Sylvain
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorRITTER, Philippe
hal.structure.identifierIHU-LIRYC
dc.contributor.authorJAÏS, Pierre
hal.structure.identifierIHU-LIRYC
dc.contributor.authorVIGMOND, Edward J.
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorPOTSE, Mark
hal.structure.identifierIHU-LIRYC
dc.contributor.authorWALTON, Richard D.
hal.structure.identifierIHU-LIRYC
dc.contributor.authorDUBOIS, Rémi
hal.structure.identifierIHU-LIRYC
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorBERNUS, Olivier
dc.date.accessioned2024-04-04T03:03:06Z
dc.date.available2024-04-04T03:03:06Z
dc.date.issued2018-05
dc.date.conference2018-05-09
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/193045
dc.description.abstractEnBackground: The mechanisms of ventricular fibrillation (VF) are classically distinguished in triggers versus substrate. However, their respective location in patients with structural heart disease (SHD) has not been investigated.Objective: To precisely locate trigger and substrate in patients presenting spontaneous VFMethods: Within a 5 year inclusion period, we investigated 14 patients (57±10 years) presenting a documented spontaneous episode of VF (lasting 16± 8s before cardioversion) associated with ischemic heart disease in 8, cardiomyopathy in 4 , and Brugada syndrome in 2. VF mapping was performed using multielectrode intracardiac and body-surface recordings. The VF trigger was located at the site of earliest ventricular activation. Reentrant drivers were identified during VF using phase mapping and confirmed by the demonstration of sequential circular activation of local electrograms. We performed endocardial and epicardial mapping during sinus rhythm. The abnormal substrate was identified as areas of low voltage (≤1mV) and fragmented electrograms (≥70ms).Results:The first beat of VF originated from Purkinje network in 8 and ventricular myocardium in 6; with the earliest endocardial electrogram preceding the QRS onset by 54 ±12ms . While myocardial triggers showed a single breakthrough on body surface mapping, Purkinje triggers were associated with simultaneous emergence of multiple breakthroughs. The transition from a focal trigger to a reentrant activity occurred at a median of 4 VF cycles [range: 2-7 cycles]. Mapping at the trigger sites showed low voltage fragmented electrograms during sinus rhythm in 12/14 patients.During VF, a driver region was consistently found to colocalize with the site of triggers in 12 patients, accounting for 34±10% of the total driver activities Catheter ablation was performed at these “trigger-driver” regions resulting in abolition of abnormal electrograms and arrhythmia-free outcome in 10 of 12 patients at 18±15 months follow up.Conclusion: Purkinje focal activity may show several ventricular exit sites. In most patients with SHD, the sites of VF triggers are intertwined with the maintaining substrate, providing a dual mechanistic target for interventional treatment.
dc.language.isoen
dc.publisherHeart Rhythm Society
dc.title.enTrigger and Substrate Share A Common Location In Human VF
dc.typeCommunication dans un congrès
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.conference.titleHeart Rhythm Meeting - HRS 39th Annual Scientific Sessions
bordeaux.countryUS
bordeaux.conference.cityBoston
bordeaux.peerReviewedoui
hal.identifierhal-01954670
hal.version1
hal.invitednon
hal.proceedingsnon
hal.conference.end2018-05-12
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01954670v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2018-05&rft.au=HA%C3%8FSSAGUERRE,%20Michel&HOCINI,%20Meleze&PUYO,%20St%C3%A9phane&CHENITI,%20Ghassen&DUCHATEAU,%20Josselin&rft.genre=unknown


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