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Intradermal injection of a Tat Oyi-based therapeutic HIV vaccine reduces of 1.5 log copies/mL the HIV RNA rebound median and no HIV DNA rebound following cART interruption in a phase I/II randomized controlled clinical trial

hal.structure.identifierInstitut méditerranéen de biodiversité et d'écologie marine et continentale [IMBE]
dc.contributor.authorLORET, Erwann
hal.structure.identifierHôpital de la Conception [CHU - APHM] [LA CONCEPTION]
dc.contributor.authorDARQUE, Albert
hal.structure.identifierHôpital de la Timone [CHU - APHM] [TIMONE]
dc.contributor.authorJOUVE, Elisabeth
dc.contributor.authorLORET, Elvenn
hal.structure.identifierAix-Marseille Université - Faculté de pharmacie [AMU PHARM]
dc.contributor.authorNICOLINO-BRUNET, Corinne
hal.structure.identifierCentre d'Investigation Clinique [Hôpital de la Conception - APHM] [CIC]
dc.contributor.authorMORANGE, Sophie
hal.structure.identifierAssistance Publique - Hôpitaux de Marseille [APHM]
dc.contributor.authorCASTANIER, Elisabeth
hal.structure.identifierAssistance Publique - Hôpitaux de Marseille [APHM]
dc.contributor.authorCASANOVA, Josiane
hal.structure.identifierInstitut de Biologie du Développement de Marseille [IBDM]
dc.contributor.authorCALOUSTIAN, Christine
hal.structure.identifierAssistance Publique - Hôpitaux de Marseille [APHM]
dc.contributor.authorBORNET, Charleric
hal.structure.identifierHôpital de la Conception [CHU - APHM] [LA CONCEPTION]
dc.contributor.authorCOUSSIROU, Julie
hal.structure.identifierHôpital de la Conception [CHU - APHM] [LA CONCEPTION]
dc.contributor.authorBOUSSETTA, Jihen
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorCOUALLIER, Vincent
hal.structure.identifierClinical Investigation Centre (CIC-UPCET) and Department of Clinical Pharmacology,
dc.contributor.authorBLIN, Olivier
hal.structure.identifierChirurgie urologique et transplantation rénale [Hôpital de la Conception - APHM]
dc.contributor.authorDUSSOL, Bertrand
hal.structure.identifierService des Maladies Infectieuses et Tropicales [Hôpital de la Conception] [SMIT]
dc.contributor.authorRAVAUX, Isabelle
dc.date.accessioned2024-04-04T03:01:39Z
dc.date.available2024-04-04T03:01:39Z
dc.date.issued2016-12
dc.identifier.issn1742-4690
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/192916
dc.description.abstractEnBackground: A Tat Oyi vaccine preparation was administered with informed consent to 48 long-term HIV-1 infected volunteers whose viral loads had been suppressed by antiretroviral therapy (cART). These volunteers were rand-omized in double-blind method into four groups (n = 12) that were injected intradermally with 0, 11, 33, or 99 µg of synthetic Tat Oyi proteins in buffer without adjuvant at times designated by month 0 (M0), M1 and M2, respectively. The volunteers then underwent a structured treatment interruption between M5 and M7. Results: The primary outcomes of this phase I/IIa clinical trial were the safety and lowering the extent of HIV RNA rebound after cART interruption. Only one undesirable event possibly due to vaccination was observed. The 33 µg dose was most effective at lowering the extent of HIV RNA and DNA rebound (Mann and Whitney test, p = 0.07 and p = 0.001). Immune responses against Tat were increased at M5 and this correlated with a low HIV RNA rebound at M6 (p = 0.01). Conclusion: This study suggests in vivo that extracellular Tat activates and protects HIV infected cells. The Tat Oyi vaccine in association with cART may provide an efficient means of controlling the HIV-infected cell reservoir.
dc.language.isoen
dc.publisherBioMed Central
dc.subject.enART interruption
dc.subject.enVaccine
dc.subject.enClinical trial
dc.subject.enTat
dc.subject.enHIV
dc.title.enIntradermal injection of a Tat Oyi-based therapeutic HIV vaccine reduces of 1.5 log copies/mL the HIV RNA rebound median and no HIV DNA rebound following cART interruption in a phase I/II randomized controlled clinical trial
dc.typeArticle de revue
dc.identifier.doi10.1186/s12977-016-0251-3
dc.subject.halSciences du Vivant [q-bio]
dc.subject.halSciences du Vivant [q-bio]/Immunologie
dc.subject.halSciences du Vivant [q-bio]/Immunologie/Vaccinologie
bordeaux.journalRetrovirology
bordeaux.volume13
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue1
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-02077548
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02077548v1
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