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Genome sequencing for rightward hemispheric language dominance

hal.structure.identifierMax Planck Institute for Psycholinguistics
dc.contributor.authorCARRION‐CASTILLO, Amaia
hal.structure.identifierGhent University Hospital
dc.contributor.authorVAN DER HAEGEN, Lise
hal.structure.identifier[GIN] Grenoble Institut des Neurosciences [GIN]
dc.contributor.authorTZOURIO‐MAZOYER, Nathalie
hal.structure.identifierMax Planck Institute for Psycholinguistics
dc.contributor.authorKAVAKLIOGLU, Tulya
hal.structure.identifierLaboratoire de Neuroimagerie Assistée par Ordinateur [LNAO]
dc.contributor.authorBADILLO, Solveig
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierQuality control and dynamic reliability [CQFD]
hal.structure.identifierEcole Nationale Supérieure de Cognitique [ENSC]
dc.contributor.authorCHAVENT, Marie
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierQuality control and dynamic reliability [CQFD]
dc.contributor.authorSARACCO, Jérôme
hal.structure.identifierUniversiteit Gent = Ghent University = Université de Gand [UGENT]
dc.contributor.authorBRYSBAERT, Marc
hal.structure.identifierÉcole des hautes études en sciences sociales [EHESS]
dc.contributor.authorFISHER, Simon
hal.structure.identifier[GIN] Grenoble Institut des Neurosciences [GIN]
dc.contributor.authorMAZOYER, Bernard
hal.structure.identifierDonders Institute for Brain, Cognition and Behaviour
dc.contributor.authorFRANCKS, Clyde
dc.date.accessioned2024-04-04T03:01:27Z
dc.date.available2024-04-04T03:01:27Z
dc.date.issued2019-04-04
dc.identifier.issn1601-1848
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/192903
dc.description.abstractEnMost people have left‐hemisphere dominance for various aspects of language processing, but only roughly 1% of the adult population has atypically reversed, rightward hemispheric language dominance (RHLD). The genetic‐developmental program that underlies leftward language laterality is unknown, as are the causes of atypical variation. We performed an exploratory whole‐genome‐sequencing study, with the hypothesis that strongly penetrant, rare genetic mutations might sometimes be involved in RHLD. This was by analogy with situs inversus of the visceral organs (left‐right mirror reversal of the heart, lungs etc.), which is sometimes due to monogenic mutations. The genomes of 33 subjects with RHLD were sequenced, and analysed with reference to large population‐genetic datasets, as well as thirty‐four subjects (14 left‐handed) with typical language laterality. The sample was powered to detect rare, highly penetrant, monogenic effects if they would be present in at least 10 of the 33 RHLD cases and no controls, but no individual genes had mutations in more than 5 RHLD cases while being un‐mutated in controls. A hypothesis derived from invertebrate mechanisms of left‐right axis formation led to the detection of an increased mutation load, in RHLD subjects, within genes involved with the actin cytoskeleton. The latter finding offers a first, tentative insight into molecular genetic influences on hemispheric language dominance.
dc.language.isoen
dc.publisherWiley
dc.title.enGenome sequencing for rightward hemispheric language dominance
dc.typeArticle de revue
dc.identifier.doi10.1111/gbb.12572
dc.subject.halSciences cognitives/Neurosciences
bordeaux.journalGenes, Brain and Behavior
bordeaux.pagee12572
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-02093544
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02093544v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Genes,%20Brain%20and%20Behavior&rft.date=2019-04-04&rft.spage=e12572&rft.epage=e12572&rft.eissn=1601-1848&rft.issn=1601-1848&rft.au=CARRION%E2%80%90CASTILLO,%20Amaia&VAN%20DER%20HAEGEN,%20Lise&TZOURIO%E2%80%90MAZOYER,%20Nathalie&KAVAKLIOGLU,%20Tulya&BADILLO,%20Solveig&rft.genre=article


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