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Fibrillation Patterns Creep and Jump in a Detailed Three-Dimensional Model of the Human Atria

hal.structure.identifierIHU-LIRYC
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorPOTSE, Mark
hal.structure.identifierInstitut de génie biomédical [Montreal] [IGB]
dc.contributor.authorVINET, Alain
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
dc.contributor.authorGHARAVIRI, Ali
hal.structure.identifierCenter for Computational Medicine in Cardiology [Lugano]
dc.contributor.authorPEZZUTO, Simone
dc.contributor.editorYves Coudière
dc.contributor.editorValéry Ozenne
dc.contributor.editorEdward Vigmond
dc.contributor.editorNejib Zemzemi
dc.date.accessioned2024-04-04T03:00:47Z
dc.date.available2024-04-04T03:00:47Z
dc.date.issued2019-05-30
dc.date.conference2019-06-06
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/192847
dc.description.abstractEnActivation mapping in animal models of atrial fibrillation (AF) has shown that activation patterns can repeat for several cycles and then be followed by different changing or repetitive patterns. Subsequent clinical studies have suggested a similar type of activity in human AF. Our purpose was to investigate whether a computer model of human AF can reproduce this behavior. We used a three-dimensional model of the human atria consisting of 0.2-mm volumetric elements with a detailed representation of bundle structures and fiber orientations. Propagating activation was simulated over 9 seconds with a monodomain reaction-diffusion model using human atrial membrane dynamics. AF was induced by rapid pacing. Pattern recurrence was quantified using a similarity measure based on transmembrane voltage at 1000 uniformly distributed points in the model. Recurrence plots demonstrated a continuous evolution of patterns, but the speed of evolution varied considerably. Groups of upto 15 similar cycles could be recognized, separated by rapid changes. In a few cases truly periodic patterns developed, which were related to macroscopic anatomical reentry. The drivers of non-periodic patterns could not be clearly identified. For example, a spiral wave could appear or disappear without an obvious impact on the similarity between cycles. We conclude that our model can indeed reproduce strong variations in similarity between subsequent cycles, but true periodicity only in case of anatomical reentry.
dc.description.sponsorshipL'Institut de Rythmologie et modélisation Cardiaque - ANR-10-IAHU-0004
dc.language.isoen
dc.publisherSpringer
dc.subject.enAtrial fibrillation
dc.subject.enRecurrence plot
dc.subject.enComputer model
dc.subject.enReentry
dc.title.enFibrillation Patterns Creep and Jump in a Detailed Three-Dimensional Model of the Human Atria
dc.typeCommunication dans un congrès
dc.identifier.doi10.1007/978-3-030-21949-9_15
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
dc.subject.halInformatique [cs]/Calcul parallèle, distribué et partagé [cs.DC]
dc.subject.halInformatique [cs]/Modélisation et simulation
dc.subject.halScience non linéaire [physics]
bordeaux.page131-138
bordeaux.volume11504
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.conference.titleFIMH 2019 - 10th International Conference Functionnal Imaging and Modeling of the Heart
bordeaux.countryFR
bordeaux.conference.cityBordeaux
bordeaux.peerReviewedoui
hal.identifierhal-02153733
hal.version1
hal.invitednon
hal.proceedingsoui
hal.conference.organizerYves Coudière
hal.conference.organizerValéry Ozenne
hal.conference.organizerEdward Vigmond
hal.conference.organizerNejib Zemzemi
hal.conference.end2019-06-08
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02153733v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2019-05-30&rft.volume=11504&rft.spage=131-138&rft.epage=131-138&rft.au=POTSE,%20Mark&VINET,%20Alain&GHARAVIRI,%20Ali&PEZZUTO,%20Simone&rft.genre=unknown


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