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Influence of Different Isoflurane Anesthesia Protocols on Murine Cerebral Hemodynamics measured with pseudo-Continuous Arterial Spin Labeling

hal.structure.identifierLeiden University Medical Center [LUMC]
dc.contributor.authorMUNTING, Leon
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorDERIEPPE, Marc
hal.structure.identifierLeiden University Medical Center [LUMC]
dc.contributor.authorSUIDGEEST, Ernst
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation Mathématique pour l'Oncologie [MONC]
dc.contributor.authorDENIS DE SENNEVILLE, Baudouin
hal.structure.identifierUniversity College of London [London] [UCL]
dc.contributor.authorWELLS, Jack
hal.structure.identifierLeiden University Medical Center [LUMC]
dc.contributor.authorVAN DER WEERD, Louise
dc.date.accessioned2024-04-04T02:58:51Z
dc.date.available2024-04-04T02:58:51Z
dc.date.issued2019-06-15
dc.identifier.issn0952-3480
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/192693
dc.description.abstractEnArterial spin labeling (ASL)-MRI can noninvasively map cerebral blood flow (CBF) and cerebrovascular reactivity (CVR), potential biomarkers of cognitive impairment and dementia. Mouse models of disease are frequently used in translational MRI studies, which are commonly performed under anesthesia. Understanding the influence of the specific anesthesia protocol used on the measured parameters is important for accurate interpretation of hemodynamic studies with mice. Isoflurane is a frequently used anesthetic with vasodilative properties. Here, the influence of three distinct isoflurane protocols was studied with pseudo-continuous ASL in two different mouse strains. The first protocol was a free-breathing set-up with medium concentrations, the second a free-breathing set-up with low induction and maintenance concentrations, and the third a set-up with medium concentrations and mechanical ventilation. A protocol with the vasoconstrictive anesthetic medetomidine was used as a comparison. As expected, medium isoflurane anesthesia resulted in significantly higher CBF and lower CVR values than medetomidine (median whole-brain CBF of 157.7 vs 84.4 mL/100 g/min and CVR of 0.54 vs 51.7% in C57BL/6 J mice). The other two isoflurane protocols lowered the CBF and increased the CVR values compared with medium isoflurane anesthesia, without obvious differences between them (median whole-brain CBF of 138.9 vs 131.7 mL/100 g/min and CVR of 10.0 vs 9.6%, in C57BL/6 J mice). Furthermore, CVR was shown to be dependent on baseline CBF, regardless of the anesthesia protocol used.
dc.language.isoen
dc.publisherWiley
dc.subject.enArterial spin labeling (ASL)-MRI
dc.subject.enAnesthesia
dc.subject.enBrain
dc.subject.enHemodynamics
dc.subject.enIsoflurane
dc.subject.enMouse
dc.title.enInfluence of Different Isoflurane Anesthesia Protocols on Murine Cerebral Hemodynamics measured with pseudo-Continuous Arterial Spin Labeling
dc.typeArticle de revue
dc.identifier.doi10.1002/nbm.4105
dc.subject.halSciences de l'ingénieur [physics]/Traitement du signal et de l'image
bordeaux.journalNMR in Biomedicine
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-02377668
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02377668v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=NMR%20in%20Biomedicine&rft.date=2019-06-15&rft.eissn=0952-3480&rft.issn=0952-3480&rft.au=MUNTING,%20Leon&DERIEPPE,%20Marc&SUIDGEEST,%20Ernst&DENIS%20DE%20SENNEVILLE,%20Baudouin&WELLS,%20Jack&rft.genre=article


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