Mostrar el registro sencillo del ítem
High-Dimensional Multi-Block Analysis of Factors Associated with Thrombin Generation Potential
hal.structure.identifier | Vaccine Research Institute [Créteil, France] [VRI] | |
dc.contributor.author | LORENZO, Hadrien | |
hal.structure.identifier | Université de Bordeaux [UB] | |
hal.structure.identifier | Institut National de la Santé et de la Recherche Médicale [INSERM] | |
dc.contributor.author | RAZZAQ, Misbah | |
hal.structure.identifier | KTH Royal Institute of Technology [Stockholm] [KTH ] | |
dc.contributor.author | ODEBER, Jacob | |
hal.structure.identifier | Hôpital de la Timone [CHU - APHM] [TIMONE] | |
dc.contributor.author | MORANGE, Pierre-Emmanuel | |
hal.structure.identifier | Quality control and dynamic reliability [CQFD] | |
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
hal.structure.identifier | Ecole Nationale Supérieure de Cognitique [ENSC] | |
dc.contributor.author | SARACCO, Jérôme | |
hal.structure.identifier | Université de Bordeaux [UB] | |
hal.structure.identifier | Institut National de la Santé et de la Recherche Médicale [INSERM] | |
dc.contributor.author | TRÉGOUËT, David-Alexandre | |
hal.structure.identifier | Statistics In System biology and Translational Medicine [SISTM] | |
dc.contributor.author | THIÉBAUT, Rodolphe | |
dc.date.accessioned | 2024-04-04T02:57:53Z | |
dc.date.available | 2024-04-04T02:57:53Z | |
dc.date.conference | 2019-06-05 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/192603 | |
dc.description.abstractEn | The identification of novel biological factors associated with thrombin generation, a key biomarker of the coagulation process, remains a relevant strategy to disentangle pathophysiological mechanisms underlying the risk of venous thrombosis (VT). As part of the MARseille THrombosis Association Study (MARTHA), we measured whole blood DNA methylation levels, plasma levels of 300 proteins, 3 thrombin generation biomarkers (endogeneous thrombin potential, peak and lagtime), clinical and genetic data in 700 patients with VT. The application of a novel high-dimensional multi-levels statistical methodology we recently developed, the data driven sparse Partial Least Square method (ddsPLS), on the MARTHA datasets enabled us 1/ to confirm the role of a known mutation of the variability of endogenous thrombin potential and peak, 2/ to identify a new signature of 7 proteins strongly associated with lagtime. | |
dc.description.sponsorship | Medical Genomics - ANR-10-LABX-0013 | |
dc.language.iso | en | |
dc.publisher | IEEE | |
dc.subject.en | Multi-Omics | |
dc.subject.en | High Dimensional Data | |
dc.subject.en | Missing Data | |
dc.subject.en | SVD | |
dc.subject.en | Partial Least Square | |
dc.subject.en | Variable Selection | |
dc.subject.en | Multi-Block Analysis | |
dc.subject.en | Machine Learning | |
dc.subject.en | Thrombine Generation | |
dc.title.en | High-Dimensional Multi-Block Analysis of Factors Associated with Thrombin Generation Potential | |
dc.type | Communication dans un congrès | |
dc.identifier.doi | 10.1109/CBMS.2019.00094 | |
dc.subject.hal | Statistiques [stat] | |
dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | |
bordeaux.page | 453-458 | |
bordeaux.hal.laboratories | Institut de Mathématiques de Bordeaux (IMB) - UMR 5251 | * |
bordeaux.institution | Université de Bordeaux | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | CNRS | |
bordeaux.conference.title | CBMS 2019 - 32nd IEEE International Symposium on Computer-Based Medical Systems (CBMS) | |
bordeaux.country | ES | |
bordeaux.conference.city | Cordoba | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-02429302 | |
hal.version | 1 | |
hal.invited | non | |
hal.proceedings | oui | |
hal.conference.end | 2019-06-07 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-02429302v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.spage=453-458&rft.epage=453-458&rft.au=LORENZO,%20Hadrien&RAZZAQ,%20Misbah&ODEBER,%20Jacob&MORANGE,%20Pierre-Emmanuel&SARACCO,%20J%C3%A9r%C3%B4me&rft.genre=unknown |
Archivos en el ítem
Archivos | Tamaño | Formato | Ver |
---|---|---|---|
No hay archivos asociados a este ítem. |