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Assessment of Intratumoral Doxorubicin Penetration after Mild Hyperthermia-mediated Release from Thermosensitive Liposomes

hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorDERIEPPE, Marc
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorESCOFFRE, Jean-Michel
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation Mathématique pour l'Oncologie [MONC]
dc.contributor.authorDENIS DE SENNEVILLE, Baudouin
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorVAN HOUTUM, Quincy
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorBARTEN-VAN RIJBROEK, Angelique
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorVAN DER WURFF-JACOBS, Kim
hal.structure.identifierMaastro Lab
dc.contributor.authorDUBOIS, Ludwig
hal.structure.identifierUniversity Medical Center [Utrecht] [UMCU]
dc.contributor.authorBOS, Clemens
hal.structure.identifierImagerie moléculaire et fonctionnelle: de la physiologie à la thérapie
dc.contributor.authorMOONEN, Chrit
dc.date.accessioned2024-04-04T02:57:39Z
dc.date.available2024-04-04T02:57:39Z
dc.date.issued2019-06-15
dc.identifier.issn1555-4309
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/192581
dc.description.abstractEnIn solid tumors, rapid local intravascular release of anticancer agents, e.g., doxorubicin (DOX), from thermosensitive liposomes (TSLs) can be an option to overcome poor extravasation of drug nanocarriers. The driving force of DOX penetration is the drug concentration gradient between the vascular compartment and the tumor interstitium. In this feasibility study, we used fibered confocal fluorescence microscopy (FCFM) to monitor in real-time DOX penetration in the interstitium of a subcutaneous tumor after its intravascular release from TSLs, Thermodox®. Cell uptake kinetics of the released DOX was quantified, along with an in-depth assessment of released-DOX penetration using an evolution model. A subcutaneous rat R1 rhabdomyosarcoma xenograft was used. The rodent was positioned in a setup including a water bath, and FCFM identification of functional vessels in the tumor tissue was applied based on AngioSense. The tumor-bearing leg was immersed in the 43°C water for preheating, and TSLs were injected intravenously. Real-time monitoring of intratumoral (i.t.) DOX penetration could be performed, and it showed the progressing DOX wave front via its native fluorescence, labeling successively all cell nuclei. Cell uptake rates (1/k) of 3 minutes were found (), and a released-DOX penetration in the range of 2500 µm2·s−1 was found in the tumor extravascular space. This study also showed that not all vessels, identified as functional based on AngioSense, gave rise to local DOX penetration.
dc.language.isoen
dc.publisherWiley
dc.title.enAssessment of Intratumoral Doxorubicin Penetration after Mild Hyperthermia-mediated Release from Thermosensitive Liposomes
dc.typeArticle de revue
dc.identifier.doi10.1155/2019/2645928
dc.subject.halSciences du Vivant [q-bio]/Biotechnologies
dc.subject.halSciences du Vivant [q-bio]/Cancer
dc.subject.halSciences du Vivant [q-bio]/Sciences pharmaceutiques
bordeaux.journalContrast Media and Molecular Imaging
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-02377672
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02377672v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Contrast%20Media%20and%20Molecular%20Imaging&rft.date=2019-06-15&rft.eissn=1555-4309&rft.issn=1555-4309&rft.au=DERIEPPE,%20Marc&ESCOFFRE,%20Jean-Michel&DENIS%20DE%20SENNEVILLE,%20Baudouin&VAN%20HOUTUM,%20Quincy&BARTEN-VAN%20RIJBROEK,%20Angelique&rft.genre=article


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