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Transmural Ventricular Heterogeneities Play a Major Role in Determining T-Wave Morphology at Different Extracellular Potassium Levels

hal.structure.identifierAragón Institute of Engineering Research [Zaragoza] [I3A]
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorBUKHARI, Hassaan
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
dc.contributor.authorPALMIERI, Flavio
hal.structure.identifierLaboratorios Rubió
dc.contributor.authorFERREIRA, Dina
hal.structure.identifierIHU-LIRYC
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorPOTSE, Mark
hal.structure.identifierQueen Mary University of London [QMUL]
dc.contributor.authorRAMÍREZ, Julia
hal.structure.identifierAragón Institute of Engineering Research [Zaragoza] [I3A]
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
dc.contributor.authorLAGUNA, Pablo
hal.structure.identifierAragón Institute of Engineering Research [Zaragoza] [I3A]
dc.contributor.authorSÁNCHEZ, Carlos
hal.structure.identifierAragón Institute of Engineering Research [Zaragoza] [I3A]
hal.structure.identifierCentro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina [CIBER-BBN]
dc.contributor.authorPUEYO, Esther
dc.date.accessioned2024-04-04T02:57:21Z
dc.date.available2024-04-04T02:57:21Z
dc.date.conference2019-09-08
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/192557
dc.description.abstractEnEnd-stage renal disease (ESRD) affects more than 10% of the world population. ESRD patients present impaired potassium homeostasis, which increases the risk for ventricular arrhythmias and sudden cardiac death. Noninvasive estimation of serum potassium, [K+], before the patient experiences serious consequences is of major importance. In this study, we investigated the relationship of [K+] with three T-wave morphological descriptors: the T-wave width (Tw), slope-to-amplitude ratio (TSA) and temporal morphological variability (dw) from ECGs of 12 ESRD patients undergoing hemodialysis and from simulated ECGs. Spearman’s correlation coefficients between the descriptors Tw, TSA and dw and [K+] were -0.5, 0.8 and 0.65, respectively. These associations were, however, highly patient-dependent. The high inter-individual variability in T-wave morphology, particularly observed at high [K+], was reproduced in the simulations and could be explained by differences in transmural heterogeneities, with 10% variations in the proportion of midmyocardial cells leading to changes larger than 15% in T-wave morphology. In conclusion, T-wave morphological descriptors have the potential to be used as predictors of [K+] in ESRD patients, but their associated inter-individual variability should be taken into account, especially under hyperkalemic conditions.
dc.language.isoen
dc.source.titleComputing in Cardiology
dc.title.enTransmural Ventricular Heterogeneities Play a Major Role in Determining T-Wave Morphology at Different Extracellular Potassium Levels
dc.typeCommunication dans un congrès
dc.identifier.doi10.22489/CinC.2019.404
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
dc.subject.halMathématiques [math]
bordeaux.volume46
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.conference.titleCinC 2019 - Computing in Cardiology 2019
bordeaux.countrySG
bordeaux.title.proceedingComputing in Cardiology
bordeaux.conference.citySingapour
bordeaux.peerReviewedoui
hal.identifierhal-02476011
hal.version1
hal.invitednon
hal.proceedingsoui
hal.conference.end2019-09-11
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02476011v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.btitle=Computing%20in%20Cardiology&rft.volume=46&rft.au=BUKHARI,%20Hassaan&PALMIERI,%20Flavio&FERREIRA,%20Dina&POTSE,%20Mark&RAM%C3%8DREZ,%20Julia&rft.genre=unknown


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