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How much can diptera-borne viruses persist over unfavourable seasons

hal.structure.identifierBiologie, Epidémiologie et analyse de risque en Santé Animale [BIOEPAR]
dc.contributor.authorCHARRON, Maud
hal.structure.identifierContrôle des maladies animales exotiques et émergentes [UMR CMAEE]
dc.contributor.authorBALENGHIEN, Thomas
hal.structure.identifierÉcole nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique [ONIRIS]
dc.contributor.authorSEEGERS, Henry
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorLANGLAIS, Michel
hal.structure.identifierÉcole nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique [ONIRIS]
dc.contributor.authorEZANNO, Pauline
dc.date.accessioned2024-04-04T02:54:25Z
dc.date.available2024-04-04T02:54:25Z
dc.date.created2012
dc.date.issued2013-09
dc.identifier.issn1932-6203
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/192274
dc.description.abstractEnDiptera are vectors of major human and animal pathogens worldwide, such as dengue, West-Nile or bluetongue viruses. In seasonal environments, vector-borne disease occurrence varies with the seasonal variations of vector abundance. We aimed at understanding how diptera-borne viruses can persist for years under seasonal climates while vectors overwinter, which should stop pathogen transmission during winter. Modeling is a relevant integrative approach for investigating the large panel of persistence mechanisms evidenced through experimental and observational studies on specific biological systems. Inter-seasonal persistence of virus may occur in hosts due to viremia duration, chronic infection, or vertical transmission, in vector resistance stages, and due to a low continuous transmission in winter. Using a generic stochastic modeling framework, we determine the parameter ranges under which virus persistence could occur via these different mechanisms. The parameter ranges vary according to the host demographic regime: for a high host population turnover, persistence increases with the mechanism parameter, whereas for a low turnover, persistence is maximal for an optimal range of parameter. Persistence in hosts due to long viremia duration in a few hosts or due to vertical transmission is an effective strategy for the virus to overwinter. Unexpectedly, a low continuous transmission during winter does not give rise to certain persistence, persistence barely occurring for a low turnover of the susceptible population. We propose a generic framework adaptable to most diptera-borne diseases. This framework allows ones to assess the plausibility of each persistence mechanism in real epidemiological situations and to compare the range of parameter values theoretically allowing persistence with the range of values determined experimentally.
dc.language.isoen
dc.publisherPublic Library of Science
dc.title.enHow much can diptera-borne viruses persist over unfavourable seasons
dc.typeArticle de revue
dc.identifier.doi10.1371/journal.pone.0074213
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologie
dc.subject.halSciences de l'environnement/Biodiversité et Ecologie
bordeaux.journalPLoS ONE
bordeaux.pagee74213
bordeaux.volume8
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue9
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-00992684
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00992684v1
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