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Simulating ventricular systolic motion in a four-chamber heart model with spatially varying robin boundary conditions to model the effect of the pericardium

hal.structure.identifierKing‘s College London
dc.contributor.authorSTROCCHI, Marina
hal.structure.identifierMedical University Graz
dc.contributor.authorGSELL, Matthias
hal.structure.identifierMedical University Graz
dc.contributor.authorAUGUSTIN, Christoph
hal.structure.identifierKing‘s College London
dc.contributor.authorRAZEGHI, Orod
hal.structure.identifierKing‘s College London
dc.contributor.authorRONEY, Caroline
hal.structure.identifierMedical University Graz
dc.contributor.authorPRASSL, Anton
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorVIGMOND, Edward
hal.structure.identifierKing‘s College London
dc.contributor.authorBEHAR, Jonathan
hal.structure.identifierKing‘s College London
dc.contributor.authorGOULD, Justin
hal.structure.identifierImaging Sciences and Biomedical Engineering Division [London]
dc.contributor.authorRINALDI, Christopher
hal.structure.identifierKing‘s College London
dc.contributor.authorBISHOP, Martin
hal.structure.identifierEuropean Space Research and Technology Centre [ESTEC]
hal.structure.identifierMedical University Graz
dc.contributor.authorPLANK, Gernot
hal.structure.identifierKing‘s College London
dc.contributor.authorNIEDERER, Steven
dc.date.accessioned2024-04-04T02:51:49Z
dc.date.available2024-04-04T02:51:49Z
dc.date.issued2020-03
dc.identifier.issn0021-9290
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/192008
dc.description.abstractEnThe pericardium affects cardiac motion by limiting epicardial displacement normal to the surface. In computational studies, it is important for the model to replicate realistic motion, as this affects the physiological fidelity of the model. Previous computational studies showed that accounting for the effect of the pericardium allows for a more realistic motion simulation. In this study, we describe the mechanism through which the pericardium causes improved cardiac motion. We simulated electrical activation and contraction of the ventricles on a four-chamber heart in the presence and absence of the effect of the pericardium. We simulated the mechanical constraints imposed by the pericardium by applying normal Robin boundary conditions on the ventricular epicardium. We defined a regional scaling of normal springs stiffness based on image-derived motion from CT images. The presence of the pericardium reduced the error between simulated and image-derived end-systolic configurations from 12.8±4.1 mm to 5.7±2.5 mm. First, the pericardium prevents the ventricles from spherising during isovolumic contraction, reducing the outward motion of the free walls normal to the surface and the upwards motion of the apex. Second, by restricting the inward motion of the free and apical walls of the ventricles the pericardium increases atrioventricular plane displacement by four folds during ejection. Our results provide a mechanistic explanation of the importance of the pericardium in physiological simulations of electromechanical cardiac function.
dc.language.isoen
dc.publisherElsevier
dc.subject.enApico-basal shortening
dc.subject.enCardiac electromechanics
dc.subject.enComputer models
dc.subject.enHeart failure
dc.subject.enPericardium
dc.subject.enVentricular systolic motion
dc.title.enSimulating ventricular systolic motion in a four-chamber heart model with spatially varying robin boundary conditions to model the effect of the pericardium
dc.typeArticle de revue
dc.identifier.doi10.1016/j.jbiomech.2020.109645
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale
bordeaux.journalJournal of Biomechanics
bordeaux.page109645
bordeaux.volume101
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-02885616
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02885616v1
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