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Wide-area low-energy surface stimulation of large mammalian ventricular tissue

hal.structure.identifierIHU-LIRYC
dc.contributor.authorMORENO, Angel
hal.structure.identifierThe University of Sydney
dc.contributor.authorWALTON, Richard
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorCONSTANTIN, Marion
hal.structure.identifierIHU-LIRYC
dc.contributor.authorBERNUS, Olivier
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorVIGMOND, Edward
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorBAYER, Jason
dc.date.accessioned2024-04-04T02:51:48Z
dc.date.available2024-04-04T02:51:48Z
dc.date.issued2019-12
dc.identifier.issn2045-2322
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/192007
dc.description.abstractEnThe epicardial and endocardial surfaces of the heart are attractive targets to administer antiarrhythmic electrotherapies. Electrically stimulating wide areas of the surfaces of small mammalian ventricles is straightforward given the relatively small scale of their myocardial dimensions compared to the tissue space constant and electrical field. However, it has yet to be proven for larger mammalian hearts with tissue properties and ventricular dimensions closer to humans. Our goal was to address the feasibility and impact of wide-area electrical stimulation on the ventricular surfaces of large mammalian hearts at different stimulus strengths. This was accomplished by placing long line electrodes on the ventricular surfaces of pig hearts that span wide areas, and activating them individually. Stimulus efficacy was assessed and compared between surfaces, and tissue viability was evaluated. Activation time was dependent on stimulation strength and location, achieving uniform linear stimulation at 9x threshold strength. Endocardial stimulation activated more tissue transmurally than epicardial stimulation, which could be considered a potential target for future cardiac electrotherapies. Overall, our results indicate that electrically stimulating wide areas of the ventricular surfaces of large mammals is achievable with line electrodes, minimal tissue damage, and energies under the human pain threshold (100 mJ).
dc.description.sponsorshipStimulation de surface étendue à faible intensité (WAYLESS): une nouvelle thérapie pour terminer les arythmies cardiaques létales - ANR-16-CE19-0009
dc.language.isoen
dc.publisherNature Publishing Group
dc.title.enWide-area low-energy surface stimulation of large mammalian ventricular tissue
dc.typeArticle de revue
dc.identifier.doi10.1038/s41598-019-51364-w
dc.subject.halSciences du Vivant [q-bio]
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale
bordeaux.journalScientific Reports
bordeaux.page15863
bordeaux.volume9
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue1
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-02885617
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02885617v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2019-12&rft.volume=9&rft.issue=1&rft.spage=15863&rft.epage=15863&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=MORENO,%20Angel&WALTON,%20Richard&CONSTANTIN,%20Marion&BERNUS,%20Olivier&VIGMOND,%20Edward&rft.genre=article


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