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Mechano-electric finite element model of the left atrium

hal.structure.identifierUniversity of Calgary
dc.contributor.authorSATRIANO, Alessandro
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierUniversity of Calgary
dc.contributor.authorVIGMOND, Edward
hal.structure.identifierUniversity of Pittsburgh School of Medicine
dc.contributor.authorSCHWARTZMAN, David
hal.structure.identifierUniversity of Calgary
dc.contributor.authorDI MARTINO, Elena
dc.date.accessioned2024-04-04T02:51:26Z
dc.date.available2024-04-04T02:51:26Z
dc.date.issued2018-05
dc.identifier.issn0010-4825
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/191988
dc.description.abstractEnMechanical stretch plays a major role in modulating atrial function, being responsible for beat-by-beat responses to changes in chamber preload, enabling a prompt regulation of cardiac function. Mechano-electric coupling (MEC) operates through many mechanisms and has many targets, making it experimentally difficult to isolate causes and effects especially under sinus conditions where effects are more transient and subtle. Therefore, modelling is a powerful tool to help understand the role of MEC with respect to the atrial electromechanical interaction. We propose a cellular-based computational model of the left atrium that includes a strongly coupled MEC component and mitral flow component to account for correct pressure generation in the atrial chamber as a consequence of blood volume and contraction. The method was applied to a healthy porcine left atrium. Results of the strongly coupled simulation show that strains are higher in the areas adjacent to the mitral annulus, the rim of the appendage, around the pulmonary venous trunks and at the location of the Bachmann's bundle, approximately between the mitral annulus and the region where the venous tissue transitions into atrial. These are regions where arrhythmias are likely to originate. The role of stretch-activated channels was very small for sinus rhythm for the single cardiac beat simulation, although tension development was very sensitive to stretch. The method could be applied to investigate potential therapeutic interventions acting on the mechano-electrical properties of the left atrium.
dc.language.isoen
dc.publisherElsevier
dc.subject.enComputational model
dc.subject.enLeft atrium
dc.subject.enMechano-electric coupling
dc.title.enMechano-electric finite element model of the left atrium
dc.typeArticle de revue
dc.identifier.doi10.1016/j.compbiomed.2018.02.010
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale
bordeaux.journalComputers in Biology and Medicine
bordeaux.page24-31
bordeaux.volume96
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-02885641
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02885641v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Computers%20in%20Biology%20and%20Medicine&rft.date=2018-05&rft.volume=96&rft.spage=24-31&rft.epage=24-31&rft.eissn=0010-4825&rft.issn=0010-4825&rft.au=SATRIANO,%20Alessandro&VIGMOND,%20Edward&SCHWARTZMAN,%20David&DI%20MARTINO,%20Elena&rft.genre=article


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