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Characterization of T Wave Amplitude, Duration and Morphology Changes During Hemodialysis: Relationship with Serum Electrolyte Levels and Heart Rate

hal.structure.identifierAragón Institute of Engineering Research [Zaragoza] [I3A]
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorBUKHARI, Hassaan A.
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
hal.structure.identifierCentre de Recerca en Enginyeria Biomèdica [Catalunya] [CREB]
dc.contributor.authorPALMIERI, Flavio
hal.structure.identifierWilliam Harvey Research Institute, Barts and the London Medical School
dc.contributor.authorRAMIREZ, Julia
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
hal.structure.identifierAragón Institute of Engineering Research [Zaragoza] [I3A]
dc.contributor.authorLAGUNA, Pablo
hal.structure.identifierHospital Clínico Universitario “Lozano Blesa” [Zaragoza, Spain]
dc.contributor.authorRUIZ, Jose Esteban
hal.structure.identifierLaboratorios Rubió
dc.contributor.authorFERREIRA, Dina
hal.structure.identifierIHU-LIRYC
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorPOTSE, Mark
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
hal.structure.identifierAragón Institute of Engineering Research [Zaragoza] [I3A]
hal.structure.identifierCentro Universitario de la Defensa de Zaragoza [CUD]
dc.contributor.authorSÁNCHEZ, Carlos
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
hal.structure.identifierAragón Institute of Engineering Research [Zaragoza] [I3A]
dc.contributor.authorPUEYO, Esther
dc.date2021-08
dc.date.accessioned2024-04-04T02:48:13Z
dc.date.available2024-04-04T02:48:13Z
dc.date.created2020-10
dc.date.issued2021-08
dc.identifier.issn0018-9294
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/191719
dc.description.abstractEnChronic kidney disease affects more than 10% of the world population. Changes in serum ion concentrations increase the risk for ventricular arrhythmias and sudden cardiac death, particularly in end-stage renal disease (ESRD) patients. We characterized how T wave amplitude, duration and morphology descriptors change with variations in serum levels of potassium and calcium and in heart rate, both in ESRD patients and in simulated ventricular fibers. Methods: Electrocardiogram (ECG) recordings from twenty ESRD patients undergoing hemodialysis (HD) and pseudo-ECGs (pECGs) calculated from twenty-two simulated ventricular fibers at varying transmural heterogeneity levels were processed to quantify T wave width (Tw), T wave slope-to-amplitude ratio (TS/A) and four indices of T wave morphological variability based on time warping (dw, dNLw, da and dNLa). Serum potassium and calcium levels and heart rate were measured along HD.Results: dNLa was the marker most strongly correlated with serum potassium, dw with calcium and da with heart rate, after correction for covariates. Median values of partial correlation coefficients were 0.75, -0.74 and -0.90, respectively. For all analyzed T wave descriptors,high inter-patient variability was observed in the pattern of such relationships. This variability, accentuated during the first HD time points, was reproduced in the simulations and shown to be influenced by differences in transmural heterogeneity.Conclusion: Changes in serum potassium and calcium levels and in heart rate strongly affect T wave descriptors, particularly those quantifying morphological variability. Significance: ECG markers have the potential to be used for monitoring serum ion concentrations in ESRD patients.
dc.description.sponsorshipUniversity of Bordeaux Graduate School in Digital Public Health - ANR-17-EURE-0019
dc.language.isoen
dc.publisherInstitute of Electrical and Electronics Engineers
dc.subject.enin silico modeling
dc.subject.enT wave morphology
dc.subject.enTransmural heterogeneity
dc.subject.enPotassium
dc.subject.enCalcium
dc.subject.enHeart rate
dc.subject.enHemodialysis
dc.subject.enTime warping
dc.title.enCharacterization of T Wave Amplitude, Duration and Morphology Changes During Hemodialysis: Relationship with Serum Electrolyte Levels and Heart Rate
dc.typeArticle de revue
dc.identifier.doi10.1109/TBME.2020.3043844
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
dc.subject.halSciences de l'ingénieur [physics]/Autre
dc.description.sponsorshipEuropeOvercoming the challenge of large gene transfer for the therapy of inherited retinal diseases
bordeaux.journalIEEE Transactions on Biomedical Engineering
bordeaux.page2467-2478
bordeaux.volume68
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-03076879
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03076879v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=IEEE%20Transactions%20on%20Biomedical%20Engineering&rft.date=2021-08&rft.volume=68&rft.spage=2467-2478&rft.epage=2467-2478&rft.eissn=0018-9294&rft.issn=0018-9294&rft.au=BUKHARI,%20Hassaan%20A.&PALMIERI,%20Flavio&RAMIREZ,%20Julia&LAGUNA,%20Pablo&RUIZ,%20Jose%20Esteban&rft.genre=article


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