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Revisiting the human uncinate fasciculus, its subcomponents and asymmetries with stem-based tractography and microdissection validation

hal.structure.identifier[GIN] Grenoble Institut des Neurosciences [GIN]
dc.contributor.authorHAU, Janice
hal.structure.identifierDepartment of Neurosciences, Division of Neurosurgery, “S. Chiara” Hospital, Trento APSS – 9 Largo Medaglie D’Oro, Trento, 38122, Italy
dc.contributor.authorSARUBBO, Silvio
hal.structure.identifierSherbrooke Connectivity Imaging Lab [Sherbrooke] [SCIL]
dc.contributor.authorHOUDE, Jean Christophe
hal.structure.identifierDepartment of Neurosciences, Division of Neurosurgery, “S. Chiara” Hospital, Trento APSS – 9 Largo Medaglie D’Oro, Trento, 38122, Italy
dc.contributor.authorCORSINI, Francesco
hal.structure.identifierSherbrooke Connectivity Imaging Lab [Sherbrooke] [SCIL]
dc.contributor.authorGIRARD, Gabriel
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorDELEDALLE, Charles
hal.structure.identifier[GIN] Grenoble Institut des Neurosciences [GIN]
dc.contributor.authorCRIVELLO, Fabrice
hal.structure.identifier[GIN] Grenoble Institut des Neurosciences [GIN]
dc.contributor.authorZAGO, Laure
hal.structure.identifier[GIN] Grenoble Institut des Neurosciences [GIN]
dc.contributor.authorMELLET, Emmanuel
hal.structure.identifier[GIN] Grenoble Institut des Neurosciences [GIN]
dc.contributor.authorJOBARD, Gaël
hal.structure.identifier[GIN] Grenoble Institut des Neurosciences [GIN]
dc.contributor.authorJOLIOT, Marc
hal.structure.identifier[GIN] Grenoble Institut des Neurosciences [GIN]
dc.contributor.authorMAZOYER, Bernard
hal.structure.identifier[GIN] Grenoble Institut des Neurosciences [GIN]
dc.contributor.authorTZOURIO-MAZOYER, Nathalie
hal.structure.identifierSherbrooke Connectivity Imaging Lab [Sherbrooke] [SCIL]
dc.contributor.authorDESCOTEAUX, Maxime
hal.structure.identifier[GIN] Grenoble Institut des Neurosciences [GIN]
dc.contributor.authorPETIT, Laurent
dc.date.accessioned2024-04-04T02:47:32Z
dc.date.available2024-04-04T02:47:32Z
dc.date.issued2017
dc.identifier.issn1863-2653
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/191653
dc.description.abstractEnDespite its significant functional and clinical interest, the anatomy of the uncinate fasciculus (UF) has received little attention. It is known as a ‘hook-shaped’ fascicle connecting the frontal and anterior temporal lobes and is believed to consist of multiple subcomponents. However, the knowledge of its precise connectional anatomy in humans is lacking, and its subcomponent divisions are unclear. In the present study, we evaluate the anatomy of the UF and provide its detailed normative description in 30 healthy subjects with advanced particle-filtering tractography with anatomical priors and robustness to crossing fibers with constrained spherical deconvolution. We extracted the UF by defining its stem encompassing all streamlines that converge into a compact bundle, which consisted not only of the classic hook-shaped fibers, but also of straight horizontally oriented. We applied an automatic-clustering method to subdivide the UF bundle and revealed five subcomponents in each hemisphere with distinct connectivity profiles, including different asymmetries. A layer-by-layer microdissection of the ventral part of the external and extreme capsules using Klingler’s preparation also demonstrated five types of uncinate fibers that, according to their pattern, depth, and cortical terminations, were consistent with the diffusion-based UF subcomponents. The present results shed new light on the UF cortical terminations and its multicomponent internal organization with extended cortical connections within the frontal and temporal cortices. The different lateralization patterns we report within the UF subcomponents reconcile the conflicting asymmetry findings of the literature. Such results clarifying the UF structural anatomy lay the groundwork for more targeted investigations of its functional role, especially in semantic language processing.
dc.language.isoen
dc.publisherSpringer Verlag
dc.subject.enKlingler’s dissection
dc.subject.enBrain asymmetry
dc.subject.enDiffusion-imaging tractography
dc.subject.enWhite matter anatomy
dc.subject.enUncinate fasciculus
dc.subject.enHealthy human
dc.title.enRevisiting the human uncinate fasciculus, its subcomponents and asymmetries with stem-based tractography and microdissection validation
dc.typeArticle de revue
dc.identifier.doi10.1007/s00429-016-1298-6
dc.subject.halSciences cognitives/Neurosciences
bordeaux.journalBrain Structure and Function
bordeaux.page1645-1662
bordeaux.volume222
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01382592
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01382592v1
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