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The 'Digital Twin' to enable the vision of precision cardiology

hal.structure.identifierDepartment of Engineering Science [Oxford]
dc.contributor.authorCORRAL-ACERO, Jorge
hal.structure.identifierDepartment of Computer Science [Oxford]
dc.contributor.authorMARGARA, Francesca
hal.structure.identifierKing‘s College London
dc.contributor.authorMARCINIAK, Maciej
hal.structure.identifierKing‘s College London
dc.contributor.authorRODERO, Cristobal
hal.structure.identifierUniversitat de Barcelona [UB]
dc.contributor.authorLONCARIC, Filip
hal.structure.identifierInstitut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
dc.contributor.authorFENG, Yingjing
hal.structure.identifierOslo University Hospital [Oslo]
dc.contributor.authorGILBERT, Andrew
hal.structure.identifierKing‘s College London
dc.contributor.authorFERNANDES, Joao
hal.structure.identifierAragón Institute of Engineering Research [Zaragoza] [I3A]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorBUKHARI, Hassaan
hal.structure.identifierOslo University Hospital [Oslo]
dc.contributor.authorWAJDAN, Ali
hal.structure.identifierOslo University Hospital [Oslo]
dc.contributor.authorVILLEGAS MARTINEZ, Manuel
hal.structure.identifierFEops
dc.contributor.authorSANTOS, Mariana
hal.structure.identifierMaastricht University [Maastricht]
dc.contributor.authorSHAMOHAMMDI, Mehrdad
hal.structure.identifierMaastricht University [Maastricht]
dc.contributor.authorLUO, Hongxing
hal.structure.identifierMedtronic Bakken Research Center BV
dc.contributor.authorWESTPHAL, Philip
hal.structure.identifierJohn Radcliffe Hospital [Oxford University Hospital]
dc.contributor.authorLEESON, Paul
hal.structure.identifierIBM Thomas J. Watson Research Center
dc.contributor.authorDIACHILLE, Paolo
hal.structure.identifierIBM Thomas J. Watson Research Center
dc.contributor.authorGUREV, Viatcheslav
hal.structure.identifierKing‘s College London
dc.contributor.authorMAYR, Manuel
hal.structure.identifierVirtual Physiological Human Institute [Leuven] [VPH]
dc.contributor.authorGERIS, Liesbet
hal.structure.identifierU.S. Food and Drug Administration [FDA]
dc.contributor.authorPATHMANATHAN, Pras
hal.structure.identifierU.S. Food and Drug Administration [FDA]
dc.contributor.authorMORRISON, Tina
hal.structure.identifierMedtronic Bakken Research Center BV
dc.contributor.authorCORNELUSSEN, Richard
hal.structure.identifierCardiovascular Research Institute Maastricht [CARIM]
dc.contributor.authorPRINZEN, Frits
hal.structure.identifierCardiovascular Research Institute Maastricht [CARIM]
dc.contributor.authorDELHAAS, Tammo
hal.structure.identifierInstitut d'Investigacions Biomèdiques August Pi i Sunyer [IDIBAPS]
dc.contributor.authorDOLTRA, Ada
hal.structure.identifierInstitut d'Investigacions Biomèdiques August Pi i Sunyer [IDIBAPS]
dc.contributor.authorSITGES, Marta
hal.structure.identifierInstitut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorVIGMOND, Edward
hal.structure.identifierUniversity of Oxford
dc.contributor.authorZACUR, Ernesto
hal.structure.identifierDepartment of Engineering Science [Oxford]
dc.contributor.authorGRAU, Vicente
hal.structure.identifierDepartment of Computer Science [Oxford]
dc.contributor.authorRODRIGUEZ, Blanca
hal.structure.identifierUniversity of Oslo [UiO]
dc.contributor.authorREMME, Espen
hal.structure.identifierKing‘s College London
dc.contributor.authorNIEDERER, Steven
hal.structure.identifierFEops
dc.contributor.authorMORTIER, Peter
hal.structure.identifierGE Vingmed Ultrasound AS
dc.contributor.authorMCLEOD, Kristin
hal.structure.identifierIHU-LIRYC
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorPOTSE, Mark
hal.structure.identifierAragón Institute of Engineering Research [Zaragoza] [I3A]
hal.structure.identifierBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine [CIBER-BBN]
dc.contributor.authorPUEYO, Esther
hal.structure.identifierDepartment of Computer Science [Oxford]
dc.contributor.authorBUENO-OROVIO, Alfonso
hal.structure.identifierKing‘s College London
dc.contributor.authorLAMATA, Pablo
dc.date.accessioned2024-04-04T02:47:22Z
dc.date.available2024-04-04T02:47:22Z
dc.date.issued2020-12-21
dc.identifier.issn0195-668X
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/191637
dc.description.abstractEnProviding therapies tailored to each patient is the vision of precision medicine, enabled by the increasing ability to capture extensive data about individual patients. In this position paper, we argue that the second enabling pillar towards this vision is the increasing power of computers and algorithms to learn, reason, and build the 'digital twin' of a patient. Computational models are boosting the capacity to draw diagnosis and prognosis, and future treatments will be tailored not only to current health status and data, but also to an accurate projection of the pathways to restore health by model predictions. The early steps of the digital twin in the area of cardiovascular medicine are reviewed in this article, together with a discussion of the challenges and opportunities ahead. We emphasize the synergies between mechanistic and statistical models in accelerating cardiovascular research and enabling the vision of precision medicine.
dc.description.sponsorshipL'Institut de Rythmologie et modélisation Cardiaque
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.subject.enArtificial intelligence
dc.subject.enComputational modelling
dc.subject.enDigital twin
dc.subject.enPrecision medicine
dc.title.enThe 'Digital Twin' to enable the vision of precision cardiology
dc.typeArticle de revue
dc.identifier.doi10.1093/eurheartj/ehaa159
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
bordeaux.journalEuropean Heart Journal
bordeaux.page4556–4564
bordeaux.volume41
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue48
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-02947289
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02947289v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Heart%20Journal&rft.date=2020-12-21&rft.volume=41&rft.issue=48&rft.spage=4556%E2%80%934564&rft.epage=4556%E2%80%934564&rft.eissn=0195-668X&rft.issn=0195-668X&rft.au=CORRAL-ACERO,%20Jorge&MARGARA,%20Francesca&MARCINIAK,%20Maciej&RODERO,%20Cristobal&LONCARIC,%20Filip&rft.genre=article


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