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[Systemic lupus erythematosus presenting with recurrent psychiatric disturbances]

dc.contributor.authorSIMONIN, C.
dc.contributor.authorDEVOS, D.
hal.structure.identifierLaboratoire de Neuroimagerie in Vivo [LNV]
dc.contributor.authorDE SEZE, J.
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierEuropean Organization for Nuclear Research [CERN]
dc.contributor.authorCHARPENTIER, P.
hal.structure.identifierLaboratoire de Neurosciences Fonctionnelles et Pathologies [LNFP]
dc.contributor.authorVAIVA, G.
hal.structure.identifierLaboratoire de Neurosciences Fonctionnelles et Pathologies [LNFP]
dc.contributor.authorGOUDEMAND, M.
dc.contributor.authorDUBUCQUOI, S.
hal.structure.identifierMédecine Interne
dc.contributor.authorHACHULLA, Eric
hal.structure.identifierClinique Neurologique
dc.contributor.authorDESTÉE, A.
dc.contributor.authorDEFEBVRE, L.
dc.date.accessioned2024-04-04T02:45:45Z
dc.date.available2024-04-04T02:45:45Z
dc.date.issued2004-09
dc.identifier.issn0035-3787
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/191494
dc.description.abstractEnINTRODUCTION: There is a wide range of non-specific symptoms that can reveal neurolupus, sometimes making diagnosis difficult. OBSERVATION: A 29-year-old man presented, from 1996 to 2002, three episodes of mood disorders with hetero-aggression, preceded by seizures, which resolved completely. Repeated investigations were negative except for lymphopenia, an inflammatory cerebrospinal fluid and some rare non-specific areas of high intensity signals in the white matter on the brain MRI. After a six-year course, the patient was considered to have a severe mood disorder related to a schizoid personality. A new dot-blot search for antinuclear antibodies detected anti-Sm antibodies was positive, leading to the diagnosis of neuropsychiatric lupus since the patient's symptoms fulfilling four of the American Rheumatism Association criteria (neuropsychiatric events, lymphopenia, antinuclear and anti-Sm antibodies). The patient was given monthly pulses of cyclophosphamide and remained symptom free one year after the last flare up. CONCLUSIONS: Lupus can rarely be revealed by long-standing isolated psychiatric disorders. Search for auto-antibodies, using highly specialized techniques (western blot, dot blot) should be a routine practice since antibody titres fluctuate during the course of the disease; elevated titres may correlate with exacerbations. Considering the prominence and severity of these behavior disorders, systemic diseases may often be misdiagnosed.
dc.language.isofr
dc.publisherElsevier Masson
dc.subject.meshHumans
dc.subject.meshLupus Erythematosus, Systemic
dc.subject.meshMale
dc.subject.meshMental Disorders
dc.subject.meshAdult
dc.title.en[Systemic lupus erythematosus presenting with recurrent psychiatric disturbances]
dc.typeArticle de revue
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]
bordeaux.journalRevue Neurologique
bordeaux.page811-6
bordeaux.volume160
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue8-9
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-00333803
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00333803v1
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