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MRI-Based Radiomics Input for Prediction of 2-Year Disease Recurrence in Anal Squamous Cell Carcinoma
hal.structure.identifier | Hôpital Haut-Lévêque [CHU Bordeaux] | |
dc.contributor.author | GIRAUD, Nicolas | |
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
hal.structure.identifier | Centre National de la Recherche Scientifique [CNRS] | |
hal.structure.identifier | Modélisation Mathématique pour l'Oncologie [MONC] | |
dc.contributor.author | SAUT, Olivier | |
hal.structure.identifier | Hopital Saint-Louis [AP-HP] [AP-HP] | |
dc.contributor.author | APARICIO, Thomas | |
hal.structure.identifier | Centre Azuréen de Cancérologie [Mougins, France] | |
dc.contributor.author | RONCHIN, Philippe | |
hal.structure.identifier | Institut Curie [Paris] | |
dc.contributor.author | BAZIRE, Louis-Arnaud | |
hal.structure.identifier | Fédération Francophone de Cancérologie Digestive [FFCD] | |
dc.contributor.author | BARBIER, Emilie | |
hal.structure.identifier | Institut régional de Cancérologie de Montpellier [ICM] | |
dc.contributor.author | LEMANSKI, Claire | |
hal.structure.identifier | Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille] | |
dc.contributor.author | MIRABEL, Xavier | |
hal.structure.identifier | Centre Armoricain de Radiothérapie, d'Imagerie médicale et d'Oncologie [Plérin, Saint-Brieuc] [CARIO] | |
dc.contributor.author | ETIENNE, Pierre-Luc | |
hal.structure.identifier | Hôpital Sud [CHU Rennes] | |
dc.contributor.author | LIÈVRE, Astrid | |
hal.structure.identifier | Hôpital privé Pays de Savoie | |
dc.contributor.author | CACHEUX, Wulfran | |
hal.structure.identifier | Institut de Cancérologie de Bourgogne | |
dc.contributor.author | DARUT-JOUVE, Ariane | |
hal.structure.identifier | Centre Léon Bérard [Lyon] | |
dc.contributor.author | DE LA FOUCHARDIÈRE, Christelle | |
hal.structure.identifier | CHU Bordeaux | |
dc.contributor.author | HOCQUELET, Arnaud | |
hal.structure.identifier | CHU Bordeaux | |
dc.contributor.author | TRILLAUD, Hervé | |
hal.structure.identifier | Hôpital Haut-Lévêque [CHU Bordeaux] | |
dc.contributor.author | CHARLEUX, Thomas | |
hal.structure.identifier | Hôpitaux Civils de Colmar | |
dc.contributor.author | BREYSACHER, Gilles | |
hal.structure.identifier | Groupe Hospitalier Bretagne Sud [GHBS] | |
dc.contributor.author | ARGO-LEIGNEL, Delphine | |
hal.structure.identifier | Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois] | |
dc.contributor.author | TESSIER, Alexandre | |
hal.structure.identifier | Institut de Cancérologie de la Loire Lucien Neuwirth | |
dc.contributor.author | MAGNÉ, Nicolas | |
hal.structure.identifier | Institut de Cancérologie de Strasbourg Europe [ICANS] | |
dc.contributor.author | BEN ABDELGHANI, Meher | |
hal.structure.identifier | CHU Dijon | |
dc.contributor.author | LEPAGE, Côme | |
hal.structure.identifier | Hôpital Haut-Lévêque [CHU Bordeaux] | |
dc.contributor.author | VENDRELY, Véronique | |
dc.date.accessioned | 2024-04-04T02:44:04Z | |
dc.date.available | 2024-04-04T02:44:04Z | |
dc.date.issued | 2021-01 | |
dc.identifier.issn | 2072-6694 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/191377 | |
dc.description.abstractEn | Purpose: Chemo-radiotherapy (CRT) is the standard treatment for non-metastatic anal squamous cell carcinomas (ASCC). Despite excellent results for T1-2 stages, relapses still occur in around 35% of locally advanced tumors. Recent strategies focus on treatment intensification, but could benefit from a better patient selection. Our goal was to assess the prognostic value of pre-therapeutic MRI radiomics on 2-year disease control (DC). Methods: We retrospectively selected patients with non-metastatic ASCC treated at the CHU Bordeaux and in the French FFCD0904 multicentric trial. Radiomic features were extracted from T2-weighted pre-therapeutic MRI delineated sequences. After random division between training and testing sets on a 2:1 ratio, univariate and multivariate analysis were performed on the training cohort to select optimal features. The correlation with 2-year DC was assessed using logistic regression models, with AUC and accuracy as performance gauges, and the prediction of disease-free survival using Cox regression and Kaplan-Meier analysis. Results: A total of 82 patients were randomized in the training (n = 54) and testing sets (n = 28). At 2 years, 24 patients (29%) presented relapse. In the training set, two clinical (tumor size and CRT length) and two radiomic features (FirstOrder_Entropy and GLCM_JointEnergy) were associated with disease control in univariate analysis and included in the model. The clinical model was outperformed by the mixed (clinical and radiomic) model in both the training (AUC 0.758 versus 0.825, accuracy of 75.9% versus 87%) and testing (AUC 0.714 versus 0.898, accuracy of 78.6% versus 85.7%) sets, which led to distinctive high and low risk of disease relapse groups (HR 8.60, p = 0.005). Conclusion: A mixed model with two clinical and two radiomic features was predictive of 2-year disease control after CRT and could contribute to identify high risk patients amenable to treatment intensification with view of personalized medicine. | |
dc.language.iso | en | |
dc.publisher | MDPI | |
dc.title.en | MRI-Based Radiomics Input for Prediction of 2-Year Disease Recurrence in Anal Squamous Cell Carcinoma | |
dc.type | Article de revue | |
dc.identifier.doi | 10.3390/cancers13020193 | |
dc.subject.hal | Mathématiques [math]/Equations aux dérivées partielles [math.AP] | |
dc.subject.hal | Sciences du Vivant [q-bio]/Cancer | |
dc.subject.hal | Informatique [cs]/Modélisation et simulation | |
bordeaux.journal | Cancers | |
bordeaux.page | 193 | |
bordeaux.volume | 13 | |
bordeaux.hal.laboratories | Institut de Mathématiques de Bordeaux (IMB) - UMR 5251 | * |
bordeaux.issue | 2 | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | CNRS | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-03428535 | |
hal.version | 1 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-03428535v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cancers&rft.date=2021-01&rft.volume=13&rft.issue=2&rft.spage=193&rft.epage=193&rft.eissn=2072-6694&rft.issn=2072-6694&rft.au=GIRAUD,%20Nicolas&SAUT,%20Olivier&APARICIO,%20Thomas&RONCHIN,%20Philippe&BAZIRE,%20Louis-Arnaud&rft.genre=article |
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