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Spatial mechanistic modeling for prediction of 3D multicellular spheroids behavior upon exposure to high intensity pulsed electric fields

hal.structure.identifierModélisation Mathématique pour l'Oncologie [MONC]
dc.contributor.authorCOLLIN, Annabelle
hal.structure.identifierModélisation Mathématique pour l'Oncologie [MONC]
dc.contributor.authorBRUHIER, Hadrien
hal.structure.identifierInstitut de pharmacologie et de biologie structurale [IPBS]
dc.contributor.authorKOLOSNJAJ, Jelena
hal.structure.identifierInstitut de pharmacologie et de biologie structurale [IPBS]
dc.contributor.authorGOLZIO, Muriel
hal.structure.identifierInstitut de pharmacologie et de biologie structurale [IPBS]
dc.contributor.authorROLS, Marie-Pierre
hal.structure.identifierModélisation Mathématique pour l'Oncologie [MONC]
dc.contributor.authorPOIGNARD, Clair
dc.date.accessioned2024-04-04T02:41:08Z
dc.date.available2024-04-04T02:41:08Z
dc.date.issued2022
dc.identifier.issn2375-1495
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/191125
dc.description.abstractEnThe objective of this work was to investigate the growth specificities of cancer cells spheroids subjected to pulsed electric field. Multicellular HCT-116-GFP spheroids were exposed to different electric field intensities and the volume of multicellular spheroids was monitored by fluorescence and bright field microscopy. Thanks to an advanced mathematical model, based on differential equations and well-adapted estimation strategies, our modeling enables us to characterize the multicellular spheroids growth after permeabilizing pulsed electric field. In particular, we identify the percentage of cells which are destroyed and the percentage of cells which exhibit an altered growth pattern for different magnitudes of the electric field. We also quantify the growth resumption upon reversible and partially irreversible electroporation. Our preliminary results provide a first quantification of the impact of electroporation on multicellular spheroids growth, and suggest a booming growth of partially irreversible electric pulses, leading to an accelerated regrowth.
dc.language.isoen
dc.publisherAIMS Press
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enPDE modeling
dc.subject.enparameters estimation
dc.subject.enelectroporation
dc.subject.enspheroids
dc.title.enSpatial mechanistic modeling for prediction of 3D multicellular spheroids behavior upon exposure to high intensity pulsed electric fields
dc.typeArticle de revue
dc.identifier.doi10.3934/bioeng.2022009
dc.subject.halMathématiques [math]
bordeaux.journalAIMS bioengineering
bordeaux.page102-122
bordeaux.volume9
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue2
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-03700689
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03700689v1
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