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Simultaneous 3D Imaging of Bone and Vessel Microstructure in a Rat Model: Measurement of Vascular-Trabecular Interdistance

hal.structure.identifierEuropean Synchrotron Radiation Facility [ESRF]
hal.structure.identifierImagerie Tomographique et Radiothérapie
dc.contributor.authorLANGER, Max
dc.contributor.authorPRISBY, Rhonda
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorPETER, Zsolt
hal.structure.identifierContraintes mécaniques et tissu osseux
dc.contributor.authorGUIGNANDON, Alain
hal.structure.identifierContraintes mécaniques et tissu osseux
hal.structure.identifierTissu Osseux et Contraintes Mecaniques [LBTO]
dc.contributor.authorLAFAGE-PROUST, Marie-Helene
hal.structure.identifierImagerie Tomographique et Radiothérapie
hal.structure.identifierEuropean Synchrotron Radiation Facility [ESRF]
dc.contributor.authorPEYRIN, Francoise
dc.date.accessioned2024-04-04T02:41:04Z
dc.date.available2024-04-04T02:41:04Z
dc.date.issued2009
dc.date.conference2009-01-25
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/191119
dc.description.abstractEnA method for simultaneous 3D imaging and analysis of microvascularization and bone microstructure in rat bone is presented. The method is based on the use of quantitative synchrotron micro-computed tomography (SR-¿CT) coupled to an automatic image analysis procedure. Previously, analysis of bone microvascularization has generally been performed from 2D histology. The proposed method enables for the first time to simultaneously analyze in 3D the microvascularization and bone microstructure in a rat model. We also propose a new parameter, utilizing the availablilty of both microstructures to relate the two, which we dub the vascular-trabecular interdistance (VTI). The proposed method was applied to investigate the effect of intermittent parathyroid hormone (PTH) administration on angiogenesis and osteogenesis in rats. It was possible to extract 3D quantitative parameters both on bone microstructure and micro-vascularization. Due to the short acquisition times of SR-¿CT and the efficiency of the image analysis algorithm, a large data set was analyzed, which permitted statistical analysis of the measured parameters. Statistical analysis showed that treatment with PTH significantly modulated several bone and vessel parameters, including the VTI.
dc.language.isoen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/
dc.title.enSimultaneous 3D Imaging of Bone and Vessel Microstructure in a Rat Model: Measurement of Vascular-Trabecular Interdistance
dc.typeCommunication dans un congrès
dc.identifier.doi10.1109/NSSMIC.2009.5401752
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale/Imagerie
bordeaux.page3344-3349
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.conference.titleIEEE Nuclear Science Symposium Conference Record (NSS/MIC) 2009
bordeaux.countryUS
bordeaux.conference.cityOrlando
bordeaux.peerReviewedoui
hal.identifierhal-01825246
hal.version1
hal.invitednon
hal.proceedingsnon
hal.conference.end2009-01-31
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01825246v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2009&rft.spage=3344-3349&rft.epage=3344-3349&rft.au=LANGER,%20Max&PRISBY,%20Rhonda&PETER,%20Zsolt&GUIGNANDON,%20Alain&LAFAGE-PROUST,%20Marie-Helene&rft.genre=unknown


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