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Malignant Purkinje Ectopy induced by Sodium-channel Blocker

hal.structure.identifierIHU-LIRYC
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorESCANDE, William
hal.structure.identifierITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 [ITX-lab]
dc.contributor.authorGOURRAUD, Jean‐baptiste
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorHAISSAGUERRE, Michel
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
hal.structure.identifierUnité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [ICAN]
dc.contributor.authorGANDJBAKHCH, Estelle
hal.structure.identifierHôpital Européen Georges Pompidou [APHP] [HEGP]
dc.contributor.authorLAVERGNE, Thomas
hal.structure.identifierCentre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
hal.structure.identifierLaboratoire Traitement du Signal et de l'Image [LTSI]
dc.contributor.authorMARTINS, Raphaël
hal.structure.identifierIHU-LIRYC
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorCHENITI, Ghassen
hal.structure.identifierUniversity Hospital Basel [Basel]
dc.contributor.authorKRISAI, Philipp
hal.structure.identifierMécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 [MP3CV]
dc.contributor.authorHERMIDA, Jean Sylvain
hal.structure.identifierCentre Hospitalier Universitaire de Toulouse [CHU Toulouse]
dc.contributor.authorMAURY, Philippe
hal.structure.identifierHospital Universitario La Paz
dc.contributor.authorMERINO, Jose-Louis
hal.structure.identifierPhysiologie & médecine expérimentale du Cœur et des Muscles [U 1046] [PhyMedExp]
hal.structure.identifierCentre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
dc.contributor.authorPASQUIÉ, Jean Luc
hal.structure.identifierClinique Pasteur [Toulouse]
dc.contributor.authorCOMBES, Nicolas
hal.structure.identifierIHU-LIRYC
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorSURGET, Elodie
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorDUCHÂTEAU, Josselin
hal.structure.identifierIHU-LIRYC
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorPAMBRUN, Thomas
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorDERVAL, Nicolas
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorHOCINI, Meleze
hal.structure.identifierIHU-LIRYC
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorJAÏS, Pierre
hal.structure.identifierAmsterdam UMC - Amsterdam University Medical Center
dc.contributor.authorPOSTEMA, Pieter
hal.structure.identifierChulalongkorn University [Bangkok]
dc.contributor.authorNADEMANEE, Koonlawee
hal.structure.identifierIHU-LIRYC
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorVIGMOND, Ed
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorBERNUS, Olivier
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorSACHER, Frédéric
hal.structure.identifierITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 [ITX-lab]
dc.contributor.authorPROBST, Vincent
dc.date.accessioned2024-04-04T02:39:44Z
dc.date.available2024-04-04T02:39:44Z
dc.date.issued2022-10
dc.identifier.issn1556-3871
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/191001
dc.description.abstractEnBackground: Sodium channel blocker (SCB) infusion is used to unmask the electrocardiographic pattern of Brugada syndrome. The test may also induce premature ventricular complexes (PVCs) in individuals without Brugada pattern, the clinical relevance of which is little known.Objective: The purpose of this study was to describe the prevalence of short-coupled (Sc) PVCs induced by ajmaline or flecainide in patients with suspected or documented severe ventricular arrhythmias.Methods: We reviewed the SCB tests performed in 335 patients with suspected ventricular arrhythmias and structurally normal hearts in 9 centers. ScPVCs were defined as frequent and repetitive PVCs with an R-on-T pattern on SCB tests. Repeated SCB tests were performed in 7 patients and electrophysiological mapping of ScPVCs in 9.Results: Sixteen patients (8 men; mean age 36 ± 11 years) showed ScPVCs and were included. ScPVCs appeared 229 ± 118 seconds after the initiation of infusion and displayed coupling intervals of 288 ± 28 ms. ScPVC patterns were monomorphic in 12 patients, originating from the Purkinje system in mapped patients. Repetitive PVCs were induced in 15 patients (94%) including polymorphic ventricular tachycardias in 9 (56%). SCB infusion was repeated 45 (interquartile range 0.6-46) months later and induced identical ScPVC in all. SCB test was the only mean to reveal the malignant arrhythmia in 6 patients. Catheter ablation was performed in 9 patients, resulting in arrhythmia elimination in 8 with a follow-up of 6 (interquartile range 2-9) years.Conclusion: SCB can induce ScPVC, mostly from Purkinje tissue, in a small subset of patients with idiopathic ventricular arrhythmias. Its high reproducibility suggests a distinct individual mechanism.
dc.description.sponsorshipL'Institut de Rythmologie et modélisation Cardiaque
dc.language.isoen
dc.publisherElsevier
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/
dc.subject.enAjmaline
dc.subject.enFlecainide
dc.subject.enIdiopathic ventricular fibrillation
dc.subject.enPremature ventricular complex
dc.subject.enPurkinje system
dc.subject.meshAdulte
dc.subject.meshAjmaline
dc.subject.meshTachycardia, Ventricular
dc.subject.meshVentricular Premature Complexes
dc.subject.meshCatheter Ablation
dc.subject.meshElectrocardiography
dc.subject.meshFlecainide
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshReproducibility of Results
dc.subject.meshSodium Channel Blockers
dc.title.enMalignant Purkinje Ectopy induced by Sodium-channel Blocker
dc.typeArticle de revue
dc.identifier.doi10.1016/j.hrthm.2022.06.034
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
bordeaux.journalHeart Rhythm
bordeaux.page1595-1603
bordeaux.volume19
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue10
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-03723655
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03723655v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Heart%20Rhythm&rft.date=2022-10&rft.volume=19&rft.issue=10&rft.spage=1595-1603&rft.epage=1595-1603&rft.eissn=1556-3871&rft.issn=1556-3871&rft.au=ESCANDE,%20William&GOURRAUD,%20Jean%E2%80%90baptiste&HAISSAGUERRE,%20Michel&GANDJBAKHCH,%20Estelle&LAVERGNE,%20Thomas&rft.genre=article


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