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Impact of intraventricular septal fiber orientation on cardiac electromechanical function

dc.contributor.authorRODRÍGUEZ-PADILLA, Jairo
dc.contributor.authorPETRAS, Argyrios
dc.contributor.authorMAGAT, Julie
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorBAYER, Jason
dc.contributor.authorBIHAN-POUDEC, Yann
dc.contributor.authorEL HAMRANI, Dounia
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorRAMLUGUN, Girish
dc.contributor.authorNEIC, Aurel
dc.contributor.authorAUGUSTIN, Christoph
dc.contributor.authorVAILLANT, Fanny
dc.contributor.authorCONSTANTIN, Marion
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorBENOIST, David
dc.contributor.authorPOURTAU, Line
dc.contributor.authorDUBES, Virginie
dc.contributor.authorROGIER, Julien
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorLABROUSSE, Louis
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorBERNUS, Olivier
hal.structure.identifierInstitut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
hal.structure.identifierIHU-LIRYC
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorQUESSON, Bruno
dc.contributor.authorHAÏSSAGUERRE, Michel
dc.contributor.authorGSELL, Matthias
dc.contributor.authorPLANK, Gernot
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorOZENNE, Valéry
dc.contributor.authorVIGMOND, Edward
dc.date.accessioned2024-04-04T02:38:21Z
dc.date.available2024-04-04T02:38:21Z
dc.date.issued2022-06-01
dc.identifier.issn0363-6135
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/190869
dc.description.abstractEnCardiac fiber direction is an important factor determining the propagation of electrical activity, as well as the development of mechanical force. In this article, we imaged the ventricles of several species with special attention to the intraventricular septum to determine the functional consequences of septal fiber organization. First, we identified a dual-layer organization of the fiber orientation in the intraventricular septum of ex vivo sheep hearts using diffusion tensor imaging at high field MRI. To expand the scope of the results, we investigated the presence of a similar fiber organization in five mammalian species (rat, canine, pig, sheep, and human) and highlighted the continuity of the layer with the moderator band in large mammalian species. We implemented the measured septal fiber fields in three-dimensional electromechanical computer models to assess the impact of the fiber orientation. The downward fibers produced a diamond activation pattern superficially in the right ventricle. Electromechanically, there was very little change in pressure volume loops although the stress distribution was altered. In conclusion, we clarified that the right ventricular septum has a downwardly directed superficial layer in larger mammalian species, which can have modest effects on stress distribution. NEW & NOTEWORTHY A dual-layer organization of the fiber orientation in the intraventricular septum was identified in ex vivo hearts of large mammals. The RV septum has a downwardly directed superficial layer that is continuous with the moderator band. Electrically, it produced a diamond activation pattern. Electromechanically, little change in pressure volume loops were noticed but stress distribution was altered. Fiber distribution derived from diffusion tensor imaging should be considered for an accurate strain and stress analysis.
dc.description.sponsorshipContrôle des Ablations Radiofréquence par Thermométrie (IRM) pour Les Oreillettes et VEntricules - ANR-17-CE19-0007
dc.language.isoen
dc.publisherAmerican Physiological Society
dc.subject.enIntraventricular Septum, Fiber Orientation, Electromechanical models, Diffusion Tensor imaging, Normal structural discontinuities
dc.title.enImpact of intraventricular septal fiber orientation on cardiac electromechanical function
dc.typeArticle de revue
dc.identifier.doi10.1152/ajpheart.00050.2022
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale/Imagerie
bordeaux.journalAJP - Heart and Circulatory Physiology
bordeaux.pageH936 - H952
bordeaux.volume322
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue6
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-03869234
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03869234v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=AJP%20-%20Heart%20and%20Circulatory%20Physiology&rft.date=2022-06-01&rft.volume=322&rft.issue=6&rft.spage=H936%20-%20H952&rft.epage=H936%20-%20H952&rft.eissn=0363-6135&rft.issn=0363-6135&rft.au=RODR%C3%8DGUEZ-PADILLA,%20Jairo&PETRAS,%20Argyrios&MAGAT,%20Julie&BAYER,%20Jason&BIHAN-POUDEC,%20Yann&rft.genre=article


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